Association of the Serum Glucose Level with Fetal-Maternal Complications of Gestational Diabetes with Insulin Therapy

  • Tayyebeh Jahed Bozorgan Department of Obstetric & Gynecology, Mahdiyeh-Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Mandana Manzouri Lashgari Department of Obstetric & Gynecology, Mahdiyeh-Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Keywords: Blood glucose, Pregnancy complications, Gestational diabetes mellitus, Insulin


Gestational diabetes mellitus (GDM) is one of the important problems in pregnant women. This study conducted to determine association the level of serum glucose with fetal-maternal complications of gestational diabetes with insulin therapy. This study has been conducted as an Existing Data Study, so medical records of all pregnant women with GDM that have been treated with insulin during 2 years of study has been selected using census. The information was obtained using, medical records data. Mean level of serum glucose before and after treatment in different times according to correct level of serum glucose did not show statistical significant (P>0.05). Apgar score, time of stay in NICU, weight at the birth, base on correct level of serum glucose did not show statistical significant (P>0.05). Gestational age at the delivery, stay in hospital, diagnosis and fetal-maternal complications between two groups did not show statistical significant (P>0.05). It seems we can with screening and diagnostic GDM with suitable control of level of serum glucose and insulin therapy reduce incidence of fetal-maternal complications.


Rebarber A, Istwan NB, Russo-Stieglitz K, Cleary-= Goldman J, Rhea DJ, Stanziano GJ. Increased incidence of gestational diabetes in women receiving prophylactic 17alpha-hydroxyprogesterone caproate for prevention of recurrent preterm delivery. Diabetes Care 2007;30(9):2277-80.

Spong CY, Guillermo L, Kuboshige J, Cabalum T. Recurrence of gestational diabetes mellitus: identification of risk factors. Am J Perinatol 1998;15(1):29-33.

Oldfield MD, Donley P, Walwyn L, Scudamore I, Gregory R. Long term prognosis of women with gestational diabetes in a multiethnic population. Postgrad Med J 2007;83(980):426-30.

de Valk HW, van Nieuwaal NH, Visser GH. Pregnancy outcome in type 2 diabetes mellitus: a retrospective analysis from the Netherlands. Rev Diabet Stud 2006;3(3):134-42.

Kwik M, Seeho SK, Smith C, McElduff A, Morris JM. Outcomes of pregnancies affected by impaired glucosetolerance. Diabetes Res Clin Pract 2007;77(2):263-8.

James DK, Steer PJ, Weiner CP, Gonik B, editors. High Risk Pregnancy: Management Options. 2nd ed. Philadelphia: WB Saunders; 1999. p. 676-7.

Turrentine JE, Aviles M, Novak JS. Clinical protocol in obstetrics and gynecology. New York: Parthenon Publishing; 2000. p. 55-6.

Turok DK, Ratcliffe SD, Baxley EG. Management of gestational diabetes mellitus. Am Fam Physician 2003;68(9):1767-72.

Moore TR. Glyburide for the treatment of gestational diabetes. A critical appraisal. Diabetes Care 2007;30 Suppl 2:S209-13.

Moore LE, Briery CM, Clokey D, Martin RW, Williford NJ, Bofill JA, Morrison JC. Metformin and insulin in the management of gestational diabetes mellitus: preliminary results of a comparison. J Reprod Med 2007;52(11):1011-5.

Langer O. From educated guess to accepted practice: the use of oral antidiabetic agents in pregnancy. Clin Obstet Gynecol 2007;50(4):959-71.

Mecacci F, Carignani L, Cioni R, Bartoli E, Parretti E, La Torre P, Scarselli G, Mello G. Maternal metabolic control and perinatal outcome in women with gestational diabetes treated with regular or lispro insulin: comparison with nondiabetic pregnant women. Eur J Obstet Gynecol ReprodBiol 2003;111(1):19-24.

Lapolla A, Dalfrà MG, Spezia R, Anichini R, Bonomo M, Bruttomesso D, Di Cianni G, Franzetti I, Galluzzo A, Mello G, Menato G, Napoli A, Noacco G, Parretti E, Santini C, et al. Outcome of pregnancy in type 1 diabetic patients treated with insulin lispro or regular insulin: anItalian experience. Acta Diabetol 2008;45(1):61-6.

Hod M, Damm P, Kaaja R, Visser GH, Dunne F, Demidova I, Hansen AS, Mersebach H; Insulin Aspart Pregnancy Study Group. Fetal and perinatal outcomes in type 1 diabetes pregnancy: a randomized study comparing insulin aspart with human insulin in 322 subjects. Am J Obstet Gynecol 2008;198(2):186.e1-7.

Mathiesen ER, Kinsley B, Amiel SA, Heller S, McCance D, Duran S, Bellaire S, Raben A; Insulin Aspart Pregnancy Study Group. Maternal glycemic control and hypoglycemia in type 1 diabetic pregnancy: a randomized trial of insulin aspart versus human insulin in 322 pregnant women. Diabetes Care 2007;30(4):771-6.

American Diabetes Association. Standards of medical care in diabetes: 2008. Diabetes Care 2008;31 Suppl 1:S12-54.

Berkowitz K, Reyes C, Saadat P, Kjos SL. Fetal lung maturation. Comparison of biochemical indices in gestational diabetic and nondiabetic pregnancies. J Reprod Med. 1997 Dec;42(12):793-800.

Cousins L. Pregnancy complications among diabetic women: review 1965-1985. Obstet Gynecol Surv 1987;42(3):140-9.

Persson B, Hanson U. Neonatal morbidities in gestational diabetes mellitus. Diabetes Care 1998;21 Suppl 2:B79-84.

Yang X, Hsu-Hage B, Zhang H, Zhang C, Zhang Y, Zhang C. Women with impaired glucose tolerance during pregnancy have significantly poor pregnancy outcomes. Diabetes Care 2002;25(9):1619-24.

Hossein-Nezhad A, Maghbooli Z, Vassigh AR, Larijani B. Prevalence of gestational diabetes mellitus and pregnancy outcomes in Iranian women. Taiwan J Obstet Gynecol 2007;46(3):236-41.

Ahkter J, Qureshi R, Rahim F, Moosvi S, Rehman A, Jabbar A, Islam N, Khan MA. Diabetes in pregnancy in Pakistani women: prevalence and complications in an indigenous south Asian community. Diabet Med 1996;13(2):189-91.

Sun WJ, Yang HX. Maternal and fetal outcomes in pregnant women with abnormal glucose metabolism. Zhonghua Fu Chan Ke Za Zhi 2007;42(6):377-81.

Nordin NM, Wei JW, Naing NN, Symonds EM. Comparison of maternal-fetal outcomes in gestational diabetes and lesser degrees of glucose intolerance. J Obstet Gynaecol Res 2006;32(1):107-14.

How to Cite
Jahed Bozorgan T, Manzouri Lashgari M. Association of the Serum Glucose Level with Fetal-Maternal Complications of Gestational Diabetes with Insulin Therapy. Acta Med Iran. 49(7):442-446.