Clinical Characteristics and Remedies in 45 Iranians with Carotid Body Tumors
Carotid body tumors (CBTs) are rare, slow-growing tumors that should be considered in evaluating every lateral neck mass. This single center study was performed to define demographic features, clinical characteristics and remedies of Iranian patients with CBT. A retrospective review of prospectively collected data was done on 45 patients with 50 CBTs who have been referred to Sina Hospital, Tehran, Iran, during a 10-year period, were investigated in this study. The demographic characteristics, clinical and pathologic features, imagings, preoperative treatments, surgical approach and complications were analyzed. The study group predominantly consisted of females (82%). Age of diagnosis was 18 to 75 years old. Five patients had bilateral CBT. Family history of CBT was positive in seven patients. Most of CBTs were ≤ 3cm in size. All of the patients presented with a neck mass, mostly without pain (84%). Other symptoms included vertigo 4%, dysphasia 4% and tinnitus 2%. There was no patient with cranial nerve involvement at presentation. The most common imaging helping the diagnosis was color Doppler sonography. Three patients had preoperative embolization. All patients underwent surgery and seven patients had post-operative cranial nerve injury. Nine cases underwent external carotid artery ligation and four ones had external carotid repair. Post operative mortality rate was one patient. This study provides epidemiological data on patients with CBT in Iran, which could be useful for health care workers in prompt diagnosis and appropriate work ups for patient's families in bilateral CBTs.
Krupski WC. Uncommon disorders affecting the carotid arteries. In: Rutherford RB, editor. Vascular surgery. Vol 2. 6th ed. Philadelphia, PA: Elsevier Saunders; 2005.
Ozay B, Kurc E, Orhan G, Yucel O, Senay S, Tasdemir M, Gorur A, Aka SA. Surgery of carotid body tumour: 14 cases in 7 years. Acta Chir Belg 2008;108(1):107-11.
Saldana MJ, Salem LE, Travezan R. High altitude hypoxia
Grufferman S, Gillman MW, Pasternak LR, Peterson CL, Young WG Jr. Familial carotid body tumors: case report and epidemiologic review. Cancer 1980;46(9):2116-22.
Rodríguez-Cuevas S, López-Garza J, Labastida- Almendaro S. Carotid body tumors in inhabitants of altitudes higher than 2000 meters above sea level. Head Neck 1998;20(5):374-8.
Luna-Ortiz K, Rascon-Ortiz M, Villavicencio-Valencia V, Granados-Garcia M, Herrera-Gomez A. Carotid body tumors: review of a 20-year experience. Oral Oncol 2005;41(1):56-61.
Sajid MS, Hamilton G, Baker DM; Joint Vascular Research Group. A multicenter review of carotid body tumour management. Eur J Vasc Endovasc Surg 2007;34(2):127-30.
Atefi S, Nikeghbalian S, Yarmohammadi H, Assadi-Sabet A. Surgical management of carotid body tumours: a 24-year surgical experience. ANZ J Surg 2006;76(4):214-7.
Salehian MT, Ghoddoosi I, Marashi A. Carotid body tumor: survey of 97 patients. Arch Iran Med 2002;5(1):1.
Hallett JW Jr, Nora JD, Hollier LH, Cherry KJ Jr, Pairolero PC. Trends in neurovascular complications of surgical management for carotid body and cervical paragangliomas: a fifty-year experience with 153 tumors. J Vasc Surg 1988;7(2):284-91.
Tayyab M, Khan MR, Sophie Z. Presentation and management of carotid body tumors. J Pak Med Assoc 2003;53(7):306-10.
Arun D, Edwin S, David S, Sunil A. Surgical management of carotid body tumors: A 15-year review. Indian J Surg 2006;68(5):257-61.
Leonetti JP, Donzelli JJ, Littooy FN, Farrell BP. Perioperative strategies in the management of carotid body tumors. Otolaryngol Head Neck Surg 1997;117(1):111-5.
Knight TT Jr, Gonzalez JA, Rary JM, Rush DS. Current concepts for the surgical management of carotid body tumor. Am J Surg 2006;191(1):104-10.
Ma D, Liu M, Yang H, Ma X, Zhang C. Diagnosis and surgical treatment of carotid body tumor: A report of 18 cases. J Cardiovasc Dis Res 2010;1(3):122-4.
Williams MD, Phillips MJ, Nelson WR, Rainer WG. Carotid body tumor. Arch Surg 1992;127(8):963-7; discussion 967-8.
Vogel TR, Mousa AY, Dombrovskiy VY, Haser PB,mGraham AM. Carotid body tumor surgery: management and outcomes in the nation. Vasc Endovascular Surg 2009;43(5):457-61.
Westerband A, Hunter GC, Cintora I, Coulthard SW, Hinni ML, Gentile AT, Devine J, Mills JL. Current trends in the detection and management of carotid body tumors. J Vasc Surg 1998;28(1):84-92; discussion 92-3.
Koskas F, Vignes S, Khalil I, Koskas I, Dziekiewicz M, Elmkies F, Lamas G, Kieffer E. Carotid chemodectomas: long-term results of subadventitial resection with deliberate external carotid resection. Ann Vasc Surg 2009;23(1):67-75.
Zhang WC, Cheng JP, Li Q, Zhang L, Wang XD, Anniko M. Clinical and pathological analysis of malignant carotid body tumour: a report of nine cases. Acta Otolaryngol 2009;129(11):1320-5.