Acta Medica Iranica 2012. 50(11):785-788.

A Huge Coronary Artery Aneurysm in Osteogenesis Imperfecta: A Case Report
Shokoufeh Hajsadeghi, Scott Reza Jafarian Kerman, Hamidreza PouraliAkbar, Ronak Mohammadi


Osteogenesis imperfecta (OI) as an inherited connective tissue disorder can affect all tissues that contains type I collagen. Well-known cardiac complications of this disease such as aortic root dilatation, aortic regurgitation and mitral valve prolapse have been rarely reported in the literature. Coronary artery aneurysm is a rare cardiac complication in OI, as reported in a 19 year old female presenting with myocardial infarction and hypotension.


Aneurysm; Coronary artery; Osteogenesis imperfecta

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Forlino A, Cabral WA, Barnes AM, Marini JC. New perspectives on osteogenesis imperfecta. Nat Rev Endocrinol. 2011;7(9):540-57

Scaramuzzo L, Raffaelli L, Spinelli MS, Damis G, Maccauro G, Manicone PF. Orthopaedic and dental abnormalities in osteogenesis imperfecta: a review of the literature. J Biol Regul Homeost Agents 2011; 25(3):313-21.

Radunovic Z, Wekre LL, Diep LM, Steine K. Cardiovascular abnormalities in adults with osteogenesis imperfecta. Am Heart J 2011; 161(3):523-9.

Passmore JM, Walker WE, Fuentes F. Successful aortocoronary bypass in osteogenesis imperfecta. J Am Coll Cardiol 1987; 9(4):960-3. Coronary artery aneurysm in osteogenesis imperfecta 788 Acta Medica Iranica, Vol. 50, No. 11 (2012)

Cotrufo M, De Santo L, Della Corte A, Di Meglio F, Guerra G, Quarto C, Vitale S, Castaldo C, Montagnani S. Basal lamina structural alterations in human asymmetric aneurismatic aorta. Eur J Histochem 2005; 49(4):363-70.

Mackay EH, Banks J, Sykes B, Lee G. Structural basis for the changing physical properties of human pulmonary vessels with age. Thorax 1978; 33(3):335-44.

Bonita RE, Cohen IS, Berko BA. Valvular heart disease in osteogenesis imperfecta: presentation of a case and review of the literature. Echocardiography 2010; 27(1):69-73.

Criscitiello MG, Ronan JA Jr, Besterman EM, Schoehwetter W. Cardiovascular abnormalities in osteogenesis imperfecta. Circulation 1965; 31:255-62.


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