A Rare Cytogenetic Presentation of Acute Myeloid Leukemia (AML-M2)

  • Prasanna Kumari Department of Pathology, Cytogenetic Unit, Kidwai Memorial Institute of Oncology, Bangalore, India.
  • Bidadi LingappaKavitha Department of Pathology, Cytogenetic Unit, Kidwai Memorial Institute of Oncology, Bangalore, India.
  • Chintaparthi Obula Reddy Department of Pathology, Cytogenetic Unit, Kidwai Memorial Institute of Oncology, Bangalore, India.
  • Maiana Mangalagowri Department of Pathology, Cytogenetic Unit, Kidwai Memorial Institute of Oncology, Bangalore, India.
  • Danem Satienariana Madhumathi Department of Pathology, Hematology Unit, Kidwai Memorial Institute of Oncology, Bangalore, India.
  • Madaiah Mahadeva Prasad Department of Pathology, Cytogenetic Unit, Kidwai Memorial Institute of Oncology, Bangalore, India.
  • Hanumanthappa Vijay Raghavendra Department of Pathology, Hematology Unit, Kidwai Memorial Institute of Oncology, Bangalore, India.
  • Chennagiri Shinivasa Murthy Premalata Department of Pathology, Kidwai Memorial Institute of Oncology, Bangalore, India.
  • Kuntejowdahalli Channaviriappa Lakshmaiah Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bangalore, 560029, India.
  • Seyed Hashem Mir Mazloumi Department of Pathology, Cytogenetic Unit, Kidwai Memorial Institute of Oncology, Bangalore, India.
Keywords: Acute myeloid leukemia, Complex karyotype, Variantmyeloid leukemia, Breakpoint, Variant

Abstract

Acute myeloid leukemia (AML) with t(8;21)(q22;q22) generating the AML1/ETO fusion gene on 8q22 is a distinct type of AML t(8;21) category (WHO)/AML-M2 (FAB), generally associated with a favourable prognosis. Variant additional chromosomal abnormalities are frequently reported. We report three adult cases of this category with unusual karyotype. Bone marrow cytogenetics of case no. 1: 45,X,-Y, t(8;21)(q13;q22) with a novel breakpoint of chromosome 8 at (q13). Case no. 2: 46,X,t(X;2)(q22;q37),t(3;7)(q21;q36),t(5;14)(p15;q11),del(8)(q22) a complex rearrangement without the involvement of chromosome 21. Case no. 3: 49,XX,+5, t(8;21)(q22;q22), +16, +der(21)t(8;21)(q22;q22) with additional der(21). Endometrial in this case which was positive for myeloperoxidase (MPO) and CD117 conforming the AML infiltration. All are morphologically AML with t(8;21). Relevant literature in cytogenetic of AML-M2 is reviewed. The molecular mechanism involved in unusual rearrangements and clinical significance of them are subjected for further studies.

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How to Cite
1.
Kumari P, LingappaKavitha B, Reddy CO, Mangalagowri M, Madhumathi DS, Prasad MM, Raghavendra HV, Murthy Premalata CS, Lakshmaiah KC, Mir Mazloumi SH. A Rare Cytogenetic Presentation of Acute Myeloid Leukemia (AML-M2). Acta Med Iran. 50(12):827-830.
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