The C60-Fullerene Porphyrin Adducts for Prevention of the Doxorubicin-Induced Acute Cardiotoxicity in Rat Myocardial Cells

  • Seyed Vahid Shetab Boushehri Department of Toxicology and Pharmacology, Faculty of Pharmacy & Nanotechnology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
  • Seyed Nasser Ostad Department of Toxicology and Pharmacology, Faculty of Pharmacy & Nanotechnology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
  • Saeed Sarkar Research Center for Science and Technology in Medicine (RCSTIM), Tehran University of Medical Sciences, Tehran, Iran.
  • Dmitry A. Kuznetsov N.N. Semenov Institute for Chemical Physics, Russian Academy of Sciences, Moscow, Russian Federation.
  • Anatoly L. Buchachenko Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation.
  • Marina A. Orlova Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation.
  • Bagher Minaii Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
  • Abbas Kebriaeezadeh Department of Toxicology and Pharmacology, Faculty of Pharmacy & Nanotechnology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
  • Seyed Mahdi Rezayat Department of Medical Nanotechnology, Tehran University of Medical Sciences, Tehran, Iran.
Keywords: Fullerene nanoparticles, doxorubicin-induced cardiotoxicity, 25Mg2 , mitochondrial dysfunctions.

Abstract

This is a fullerene-based low toxic nanocationite designed for targeted delivery of the paramagnetic stable isotope of magnesium to the doxorubicin (DXR)-induced damaged heart muscle providing a prominent effect close to about 80% recovery of the tissue hypoxia symptoms in less than 24 hrs after a single injection (0.03 - 0.1 LD50). Magnesium magnetic isotope effect selectively stimulates the ATP formation in the oxygen-depleted cells due to a creatine kinase (CK) and mitochondrial respiratory chain-focusing "attack" of 25Mg2+ released by nanoparticles. These "smart nanoparticles" with membranotropic properties release the overactivating cations only in response to the intracellular acidosis. The resulting positive changes in the energy metabolism of heart cell may help to prevent local myocardial hypoxic (ischemic) disorders and, hence, to protect the heart muscle from a serious damage in a vast variety of the hypoxia-induced clinical situations including DXR side effects.

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How to Cite
1.
Shetab Boushehri SV, Ostad SN, Sarkar S, Kuznetsov DA, Buchachenko AL, Orlova MA, Minaii B, Kebriaeezadeh A, Rezayat SM. The C60-Fullerene Porphyrin Adducts for Prevention of the Doxorubicin-Induced Acute Cardiotoxicity in Rat Myocardial Cells. Acta Med Iran. (No. 5):342-350.
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