Acta Medica Iranica 2013. 51(3):195-198.

A woman with treated breast cancer, recent neurological symptoms and xanthoderma.
Vitorino Modesto dos Santos, Anna Gabriela Oliveira Camilo, Leonardo Aquino de Souza, Diogo Wagner da Silva de Souza, Christiane Silveira Marinho, Lucas Maciel Rodrigues Monteiro

Abstract


We describe a 69-year-old-woman with antecedent of breast cancer and recent transitory neurological symptoms. Physical examination showed yellow to orange skin pigmentation, more conspicuous on her palms and soles, while discoloration changes were absent in the eye and oral mucous membranes. Routine laboratory findings were not indicative of hemolytic anemia, liver or bile disorders, nephrotic syndrome, hypothyroidism or diabetes mellitus. We emphasize the role of her excessive ingestion of papaw and tomato. These foods are rich in carotenoids (β-carotene and lycopene), which are associated with pigmentation disorders. The skin discoloration improved in about two months after correction of the inadequate diet. Major concerns about differential diagnosis of yellow skin pigmentation are also highlighted.

Keywords


Carotenoids; Diet; Old aged; Pigmentation; Skin

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References


Chaparro RS, Carr E, Barron JL. Hypercarotenaemia or hypercarotenoidaemia. Ann Clin Biochem 2003;40(Pt3):280-2.

Hess AF, Myers VC. Carotinemia: a new clinical picture. JAMA 1919;73(23):1743-5.

Caroselli C, Bruno G, Manara F. A rare cutaneous case of carotenosis cutis: lycopenaemia. Ann Nutr Metab 2007;51(6):571-3.

Constanza DJ. Carotenemia associated with papaya ingestion. Calif Med 1968;109(4): 319–20.

Shaw JA, Koti M. Clinical images CMAJ 2009;180(8):895.

Namitha KK, Negi PS. Chemistry and biotechnology of carotenoids. Crit Rev Food Sci Nutr 2010;50(8):728-60.

La Placa M, Pazzaglia M, Tosti A. Lycopenaemia. J Eur Acad Dermatol Venereol 2000;14(4):311-2.

Rao AV. Lycopene, tomatoes, and the prevention of coronary heart disease. Exp Biol Med (Maywood) 2002;227(10):908-13.

Somanah J, Aruoma OI, Gunness TK, Kowelssur S, Dambala V, Murad F, Googoolye K, Daus D, Indelicato J, Bourdon E, Bahorun T. Effects of a short term supplementation of a fermented papaya preparation on biomarkers of diabetes mellitus in a randomized Mauritian population. Prev Med 2012;54 Suppl:S90-7.

Sheweita SA, Sheikh BY. Can dietary antioxidants reduce the incidence of brain tumors? Curr Drug Metab 2011;12(6):587-93.

Pogoda JM, Preston-Martin S, Howe G, Lubin F, Mueller BA, Holly EA, Filippini G, Peris-Bonet R, McCredie MR,Cordier S, Choi W. An international case-control study ofmaternal diet during pregnancy and childhood brain tumor risk: a histology-specific analysis by food group. Ann Epidemiol 2009;19(3):148-60.

Sato R, Helzlsouer KJ, Alberg AJ, Hoffman SC, Norkus EP, Comstock GW. Prospective study of carotenoids, tocopherols, and retinoid concentrations and the risk of breast cancer. Cancer Epidemiol Biomarkers Prev 2002;11(5):451-7.

Yeum KJ, Ahn SH, Rupp de Paiva SA, Lee-Kim YC, Krinsky NI, Russell RM. Correlation between carotenoid concentrations in serum and normal breast adipose tissue of women with benign breast tumor or breast cancer. J Nutr 1998;128(11):1920-6.

Kabat GC, Kim M, Adams-Campbell LL, Caan BJ, Chlebovski RT, Neuhouser ML, Shikany JM, Rohan TE. Longitudinal study of serum carotenoid, retinol, and tocopherol concentrations in relation to breast cancer risk among postmenopausal women. Am J Clin Nutr 2009;90(1):162-9.

Santos VM, Castro RA, Lima CC, Moraes MB, Sugai TAM. Skin eruption and thrombocytopaenia in a woman with glaucoma: a case report. West Indian Med J 2010;59(1):113-6.

Wageesha ND, Ekanayake S, Jansz ER, Lamabadusuriya S. Studies on hypercarotenemia due to excessive ingestion of carrot, pumpkin and papaw. Int J Food Sci Nutr 2011;62(1):20-5.


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