Evaluation of plasma concentrations of homocysteine, IL-6, TNF-alpha, hs-CRP, and total antioxidant capacity in patients with end-stage renal failure.

  • Mahin Babaei Department of Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
  • Nasrin Dashti Department of Laboratory Sciences, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran.
  • Navid Lamei Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran.
  • Khosrou Abdi Department of Radiopharmacy and Medicinal Chemistry, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
  • Farhad Nazari Department of Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
  • Sepideh Abbasian Department of Drug and Food Control, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
  • Siavash Gerayeshnejad Department of Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Keywords: End stage renal disease, Cardiovascular disease, Hemodialysis, homocysteine, Interleukins

Abstract

It has been proved that hyperhomocysteinemia has a high prevalence in patients with end-stage renal disease (ESRD), which may contribute to the high cardiovascular risk in these patients. Cardiovascular disease is the first cause of high mortality rate in ESRD patients. The aim of the present study was to assess five important factors in patients with ESRD (the amount of homocysteine, IL-6, TNF-alpha, hs-CRP, and Total Antioxidant Capacity). These factors were surveyed in ESRD patients to compare with healthy subjects. In a cross-sectional study, we enrolled 80 patients on maintenance hemodialysis and measured the inflammatory and oxidative stress indicators. The plasma samples were assayed for five above mentioned variables using standard protocols. Two-hour post hemodialysis plasma samples were also assayed for TAC. Plasma levels of inflammation markers, IL-6 and hs-CRP, homocysteine were significantly increased in ESRD group versus control group. This increase was also found in TNF-α levels as compared to the controls, but the differences were not statistically significant. Also, the post dialysis samples had significantly lower levels of TAC as compared to predialysis ones.

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How to Cite
1.
Babaei M, Dashti N, Lamei N, Abdi K, Nazari F, Abbasian S, Gerayeshnejad S. Evaluation of plasma concentrations of homocysteine, IL-6, TNF-alpha, hs-CRP, and total antioxidant capacity in patients with end-stage renal failure. Acta Med Iran. 52(12):893-898.
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