Acta Medica Iranica 2014. 52(4):323-326.

A neonate with indurate dermal papules and nodules and pneumonia: a case report.
Behdad Gharib, Mina Almasi, Sara Esmaeili, Soheila Sotoudeh, Maryam Monajemzadeh, Asghar Ramyar, Hossein Farshadmoghadam, Farah Sabouni


We presents an infant with several indurated plaques and nodules scattered on her body. She was brought to the hospital because of fever, runny nose and cough from one month ago. During the examination and investigation the plaques and nodules grabbed the attention of the clinicians and the skin biopsy and other lab works revealed the diagnosis of congenital leukemia.


Congenital leukemia; Leukemia cutis; Blueberry muffin; Noduules; Plaques

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Grundy RG, Martinez A, Kempski H, et al. Spontaneous, remission of congenital leukemia: a case for conservative treatment. J Pediatr Hematol Oncol 2000;22(3):252-5.

Sato Y, Izumi Y, Minegishi K, et al. Prenatal findings in congenital leukemia: a case report. Fetal Diagn Ther 2011;29(4):325-30.

van den Berg H, Hopman AH, Kraakman KC, et al. Spontaneous remission in congenital leukemia is not related to (mosaic) trisomy 21: case presentation and literature review. Pediatr Hematol Oncol 2004;21(2):135-44.

Jackowska T, Steczowicz M, Pawelec K, et al. Congenital leukaemia and transient myeloproliferative disorder: diagnostic difficulties--case reports. Med Wieku Rozwoj 2006 ;10(3 Pt 1):595-601.

Zhang IH, Lee LT, Braun BS, et al. Congenital leukemia cutis with subsequent development of leukemia. J Am Acad Dermatol 2006;54(2 Suppl):S22-7.

Fender AB, Gust A, Wang N, et al. Congenital leukemiacutis. Pediatr Dermatol 2008;25(1):34-7.

Zhang IH, Zane LT, Braun BS, et al. Congenital leukemia cutis with subsequent development of leukemia. J Am Acad Dermatol 2006;54(2 Suppl):S22-7.

Frontanes A, Montalvo F, Valc√°rcel M. Congenital leukemia with leukemia cutis: a case report. Bol Asoc Med P R 2012;104(1):52-4.

Sotiriou E, Manousari A, Apalla Z, et al. Aleukaemic Congenital Leukaemia Cutis: A Critical Primary Sign of Systemic Disease. Acta Derm Venereol 2011;91(2):203-4.

Choi JH, Lee HB, Park CH, et al. A case of congenitalleukemia cutis. Ann Dermatol (Seoul) 2009;21(1):66-70.

Prakash KP, Rau ATK, Bhat ST, et al. Congenital Leukemia-A diagnostic dilemma. Ind J Med Pediatr Oncol 2008;29(4):41-3.

David G. Tubergen, Archie Bleyer, and A. Kim Ritchey,Infant Leukemia. In: Kliegman RM, Stanton BMD, Geme JSt, et al, editors. Nelson Text book of Pediatrics. 19th ed. Philadelphia, United States of America: Saunders; 2011: p. 1739.

Resnik KS, Brod BB. Leukemia cutis in congenital leukemia: analysis and review of the world literature with report of additional case. Arch Dermatol 1993;129(10):1301-6.

Fender AB, Gust A, Wang N, et al. Congenital leukemia cutis. Pediatr Dermatol 2008;25(1):34-7.

Landers MC, Malempati S, Tilford D, et al. Spontaneous regression of aleukemia congenital leukemia cutis. Pediatr Dermatol 2005;22(1):26-30.

Monpoux F, Lacour JP, Hatchuel Y, et al. Congenital leukemia cutis preceding monoblastic leukemia by 3 months. Pediatr Dermatol 1996;13(6):472-6.

Mehta V, Balachandran C, Lonikar V. Blueberry muffin baby: a pictoral differential diagnosis. Dermatol Online J2008;14(2):8.

Piersigilli F, Danhaive O, Auriti C. Blueberry muffin baby due to alveolar rhabdomyosarcoma with cutaneous metastasis. Arch Dis Child Fetal Neonatal Ed 2010;95(6):F461


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