Evaluating the Effect of Four Extracts of Avocado Fruit on Esophageal Squamous Carcinoma and Colon Adenocarcinoma Cell Lines in Comparison with Peripheral Blood Mononuclear Cells
,
Abstract
Most patients with gastrointestinal cancers refer to the health centers at advanced stages of the disease and conventional treatments are not significantly effective for these patients. Therefore, using modern therapeutic approaches with lower toxicity bring higher chance for successful treatment and reduced adverse effects in such patients. The aim of this study is to evaluate the effect of avocado fruit extracts on inhibition of the growth of cancer cells in comparison with normal cells. In an experimental study, ethanol, chloroform, ethyl acetate, and petroleum extracts of avocado (Persea americana) fruit were prepared. Then, the effects if the extracts on the growth of esophageal squamous cell carcinoma and colon adenocarcinoma cell lines were evaluated in comparison with the control group using the MTT test in the cell culture medium. Effects of the four extracts of avocado fruit on three cells lines of peripheral blood mononuclear cells, esophageal squamous cell carcinoma, and colon adenocarcinoma were tested. The results showed that avocado fruit extract is effective in inhibition of cancer cell growth in comparison with normal cells (P<0.05). Avocado fruit is rich in phytochemicals, which play an important role in inhibition of growth of cancer cells. The current study for the first time demonstrates the anti-cancer effect of avocado fruit extracts on two cancers common in Iran. Therefore, it is suggested that the fruit extracts can be considered as appropriate complementary treatments in treatment of esophageal and colon cancers.
Walker DM, Boey G, McDonald LA. The pathology of oral cancer. Pathology 2003;35(5):376-83.
Mohebbi M, Mahmoodi M, Wolfe R, et al. Geographical spread of gastrointestinal tract cancer incidence in the Caspian Sea region of Iran:Spatial analysis of cancer registry data. BMC Cancer 2008;8(5):137.
Sadjadi A, Nouraie M, Mohagheghi MA, et al. Cancer occurrence in Iran in 2002, an International perspective. Asian Pac J Cancer Prev 2005;6(3):359-63.
Cancer Control Office of Ministry of Health:Iranian annual cancer registration report:2003. Tehran:Ministry of Healthpublication;2005.
Naghavi N, editor Death report from 23 provinces in Iran. 1st ed. Tehran:Ministry of Health; 2004.
Pisani P, Bray F, Parkin DM. Estimates of the World-Wide Prevalence of Cancer for 25 Sites in the Adult Population. Int J Cancer 2002;97(1):72-81.
Kumar K, Abbas AK, aster J, editors. Robbins basic Pathology. 9th ed, Piladelphia: Saunders; 2012: p. 563.
Jemal A, Bray F, Center MM, et al. Global cancer statistics. CA Cancer J Clin 2011;61(2):69-90.
Odze RD, Goldblum JR. Surgical pathology of the GI tract, liver, Billity tract, and Pancreas. 2nd ed. Philadelphia:Saunders; 2009: p. 598.
Ding H, Han C, Guo D, et al. Selective induction of apoptosis of human cancer cell lines by avocado extract via a ROS-mediated mechanism. Nutr Cancer 2009;61(3):348-56.
Butt AJ, Roberts CG, Seawright AA, et al. A noval plant toxin, persin, with in vivo activity in the mammary gland, Induces Bim-dependent apoptosis in human breast cancer cells. Mol Cancer Ther 2006;5(9):2300-9.
Lu QY, Arteaga JR, Zhang Q, et al. Inhibition of prostate cancer cell growth by an avocado extract:role of lipidsoluble bioactive substances. J Nutr Biochem 2005;16(1):23-30.
D'Ambrosio SM, Han C, Pan L, et al. Aliphatic acetogenin constituents of avocado fruits inhibit human oral cancer cell proliferation by targeting the EGFR/RAS/RAF/MEK/ERK1/2 pathway. Biochem Biophys Res Commun 2011;409(3):465-9.
Domergue F, Helms GL, Prusky D, et al. Antifungal compounds from idioblast cell isolated from avocado fruits. Phytochemistry 2000;54(2):183-9.
Ojewole JA, Amabeoku GJ. Anticonvulsant effect of Persea Americana Mill (Lauraceae) (Avacado) leaf aqueous extract in mice. Phytother Res 2006;20(8):696-700.
Rosenblat G, Meretski S, Segal J, et al. Polyhydroxylated fatty alcohols derived from avocado suppress inflammatory response and provide non- sunscreen protection against UV-induced damage in skin cells. Arch dermatol Res 2011;302(4):239-46.
Paul R, Kulkarni P, Ganesh N. Avocado fruit (Persea americana Mill) exhibits chemo-protective potentiality against cyclophosphamide induced genotoxicity in human lymphocyte culture. J Exp Ther Oncol 2011;9(3):221-30.
| Files | ||
| Issue | Vol 52, No 3 (2014) | |
| Section | Original Article(s) | |
| Keywords | ||
| Esophageal squamous cell Cancer Colon Adenocarcinoma Avocado Fruit | ||
| Rights and permissions | |
|
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
