Effects of sesame seed supplementation on inflammatory factors and oxidative stress biomarkers in patients with knee osteoarthritis.

  • Mahdieh Khadem Haghighian Department of Nutrition, Students' Research Committee, School of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Beitollah Alipoor Department of Community Nutrition, Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Aida Malek Mahdavi Department of Nutrition, Students' Research Committee, School of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Bina Eftekhar Sadat Department of Physical Medicine and Rehabilitation, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Mohammad Asghari Jafarabadi Traffic Injury Prevention Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Abdolvahab Moghaddam Department of Physical Medicine and Rehabilitation, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Keywords: Sesame, Oxidative stress, Antioxidant, Inflammation, Osteoarthritis

Abstract

Considering the high prevalence of osteoarthritis (OA) and since until now there has not been any human studies to evaluate the effect of sesame in OA patients, this study was designed to assess the effect of administration of sesame on inflammation and oxidative stress in patients with knee OA. Fifty patients with knee OA were allocated into two groups namely control and sesame group. 25 patients in the control group received 40 g placebo powder per day while 25 patients in the sesame group received 40 g of sesame seed daily during two months of study along with standard medical therapy. Serum total antioxidant capacity, malondialdehyde (MDA), high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6) were measured. In the sesame group, a significant decrease in serum MDA and hs-CRP were seen after two months of study (P<0.05). There was no significant difference in post-treatment serum values of MDA, TAC and hs-CRP between two groups (P>0.05). Serum IL-6 decreased significantly in both groups compared with baseline during the two-month study (P<0.05). There was a significant difference in mean serum IL-6 between two groups after treatment (P=0.001). Sesame seed is a natural and safe substance that may have beneficial effects in patients with knee OA, and it may provide new complementary and adjunctive treatment in these patients.

References

Duncan K. Medical Nutrition Therapy for Rheumatic Disease. In: Mahan K, Escott-stump S, editors. Krause’s Food & Nutrition Therapy. 12th ed. Philadelphia: Saunders; 2008: p. 1042-66.

Anandacoomarasamy A, March L. Current evidence for osteoarthritis treatments. Ther Adv Musculoskel Dis 2010;2(1):17-28.

Livshits G, Zhai G, Hart DJ, et al. Interleukin-6 is a significant predictor of radiographic knee osteoarthritis. Arthritis Rheum 2009;60(7):2037-45.

Bhattacharya I, Saxena R, Gupta V. Efficacy of vitamin E in knee osteoarthritis management of North Indian geriatric population. Ther Adv Musculoskel Dis 2012;4(1):11-9.

McAlindon TE, Jacques P, Zhang Y, et al. Do antioxidant micronutrients protect against the development and progression of knee osteoarthritis? Arthritis Rheum 1996;39(4):648-56.

Surapaneni K, Venkataramana G. Status of lipid peroxidation, glutathione, ascorbic acid, vitamin E and antioxidant enzymes in patients with osteoarthritis. Ind J Med Sci 2007;61(1):9-14.

Pelletier JP, Martel-Pelletier J, Abramson SB. Osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targets. Arthritis Rheum 2001;44(6):1237-47.

Benito MJ, Veale DJ, FitzGerald O, et al. Synovial tissue inflammation in early and late osteoarthritis. Ann Rheum Dis 2005;64(9):1263-7.

Clark AG, Jordan JM, Vilim V, et al. Serum cartilage oligomeric protein reflects osteoarthritis presence and severity: the Johnston County Osteoarthritis Project. Arthritis Rheum 2002;42(11):2356-64.

Sharif M, Shepstone L, Elson CJ, et al. Increased serum C-reactive protein may reflect events that precede radiographic progression in osteoarthritis of the knee. Ann Rheum Dis 2003;59(1):71-4.

Sowers M, Jannausch M, Stein E, et al. C-reactive protein as a biomarker of emergent osteoarthritis. Osteoarthr Cartilage 2002;10(8):595-601.

Haywood L, McWilliams DF, Pearson CI, et al. Inflammation and angiogenesis in osteoarthritis. Arthritis Rheum 2003;48(8):2173-7.

Bonnet C, Walsh D. Osteoarthritis, Angiogenesis and inflammation. Rhumatology 2005;44(1):7-16.

Brandt KD. Non-surgical treatment of osteoarthritis: a half century of "advances". Ann Rheum Dis 2004;63(2):117-22.

Pagnano M, Westrich G. Successful nonoperative management of chronic osteoarthritis pain of the knee: safety and efficacy of retreatment with intraarticular hyaluronans. Osteoarthr Cartilage 2005;13(9):751-61.

Ameye L, Chee W. Osteoarthritis and nutrition. From nutraceuticals to functional foods: a systematic review of the scientific evidence. J Arth Res Ther 2006;8(4):127-48.

Chen PR, Chien KL, Su TC, et al. Dietary sesame reduces serum cholesterol and enhances antioxidant capacity in hypercholesterolemia. Nutr Res 2005;25(6):559-67.

Kang MH, Naito M, Tsujihara N, et al. Sesamolin inhibits lipid peroxidation in rat liver and kidney. J Nutr 1998;128(6):1018-22.

Hirata F, Fujita K, Ishikura Y, et al. Hypocholesterolemic effect of sesame lignan in humans. Atherosclerosis 1996;122(1):135-36.

Nakano D, Itoh C, Ishii F, et al. Effects of sesamin on aortic oxidative stress and endothelial dysfunction in deoxycorticosterone acetate-salt hypertensive rats. Biol Pharm Bull 2003;26(12):1701-5.

Ikeda S, Tohyama T, Yamashita K. Dietary sesame seed and its lignans inhibit 2,7,8 trimethyl-2 (2Vcarboxyethyl)- 6-hydroxychroman excretion into urine of rats fed gamma tocopherol. J Nutr 2002;132(5):961-6.

Hsu DZ, Su SB, Chien SP, et al. Effect of sesame oil on oxidative-stress associated renal injury in endotoxemic rats: involvement of nitric oxide and proinflammatory cytokines. Shoc 2005;24(3):276-80.

Chavali SR, Zhong WW, Forse RA. Dietary alphalinolenic acid increases TNF-alpha, and decreases IL-6, IL-10 in response to LPS: effects of sesamin on the delta-5 desaturation of w6 and w3 fatty acids in mice. Prostag Leukotr Ess 1998;58(3):185-91.

Wolde TS, Engel F, Miltenburg M, et al. Sesame oil in injectable gold: Two drugs in one? Brit J Rheumatol 1997;36(9):1012-5.

Wu J, Hodgson J, Puddey I, et al. Sesame supplementation does not improve cardiovascular disease risk markers in overweight men and women. Nutr Metab Cardiovasc Dis 2009;19(11):774-80.

Altman R, Asch E, Bloch D, et al. Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association. Arthritis Rheum 1986;29(8):1039-49.

Mosallaee M, Eghtesadi SH, Kaseb F, et al. Effect of sesame oil on lipid profile and blood glucose in type 2 diabetic patients referred to the Yazd Diabetic Medical Research Center. J Shahid Sadooghi Univ Med Sci 2008;16(1):15-23.

Arden N, Nevitt MC. Osteoarthritis: epidemiology. Best Pract Res Clin Rheumatol 2006;20(1):3-25.

Tehrani-Banihashemi SA, Jamshidi AR, Nooroallahzadeh E, et al. Proceedings of 12th APLAR congress Asian Rheumatology Facing the Challenges. 1-5 August. 2006. Kuala Lampur: Malaysia.

Sankar D, Ali A, Sambandam G, et al. Sesame oil exhibits synergistic effect with anti-diabetic medication in patients with type 2 diabetes mellitus. Clin Nutr 2011;30(3):351-8.

Sankar D, Rao MR, Sambandam G, et al. A pilot study of open label sesame oil in hypertensive diabetics. J Med Food 2006;9(3):408-12.

Devarajan S, Amanat A, Ganapathy S, et al. Sesame oil exhibits synergistic effect with anti-diabetic medication in patients with type 2 diabetes mellitus. Clin Nutr 2011;30(3):351-8.

Nishant P, Visavadiya A, Narasimhacharya V. Sesame as a hypocholesteraemic and antioxidant dietary component. Food Chem Toxic 2008;46(6):1889-95.

Saif A, Seema Y, Tauheed I, et al. Effect of dietary sesame oil as antioxidant on brain hippocampus of rat in focal cerebral ischemia. Life Sci 2005;79(20):1921-8.

Kapadia J, Azuine M, Tokuda H, et al. Chemopreventive effect of resveratrol, sesamol, sesame oil and sunflower oil in the Epstein–Barr virus early antigen activation assay and the mouse skin two-stage carcinogenesis. Pharm Resh 2002;45(6):499-504.

Toyokuni S, Tanaka T, Kawaguchi W, et al. Effects of the phenolic contents of Mauritian endemic plant extract on promoter activities of antioxidant enzymes. Free Radic Res 2003;37(11):1215-24.

Ranaivo H, Rakotoarison O, Tesse A, et al. Cedrelopsis grevei induced hypotension and improved endothelial vasodilatation through an increase of Cu/Zn SOD protein expression. Am J Physiol Heart Circ Physiol 2004;286(2):H775-81.

Nakai M, Harada M, Nakahara K, et al. Novel antioxidative metabolites in rat liver with ingested sesamin. J Agric Food Chem 2003;51(6):1666-70.

Jeng K, Hou R. Sesamin and Sesamolin: Nature’s Therapeutic Lignans. Curr Enzym Inhibit 2005;1(1):11-20.

Kamal-Eldin A, Pettersson D, Appelqvist LA. Sesamin (a compound from sesame oil) increases tocopherol levels in rats fed ad libitum. Lipids 1995;30(6):499-505.

Kamal-Eldin A, Frank J, Razdan A, et al. Effects of dietary phenolic compounds on tocopherol, cholesterol, and fatty acids in rats. Lipids 2000;35(4):427-35.

Kontush A, Spranger T, Reich A, et al. Lipophilic antioxidants in blood plasma as markers of atherosclerosis: the role of alpha-carotene and gamma-tocopherol. Atherosclerosis 1999;144(1):117-22.

Arden N, Nevitt MC. Osteoarthritis: epidemiology. Best Pract Res Clin Rheumatol 2006;20(1):3-25.

Kee-Ching G, Rolis W, Jing-Cheng H, et al. Sesamin inhibits lipopolysaccharide-induced cytokine production by suppression of p38 mitogen-activated protein kinase and nuclear factor. Immunol Lett 2005;97(1):101-6.

Wang B, Chang LW, Yen WJ, et al. Antioxidative effect of sesame coat on LDL oxidation and oxidative stress in macrophages. Food Chem 2007;102(1):351-60.

Lahaie-Collins V, Bournival J, Plouffe M, et al. Sesamin modulates tyrosine hydroxylase, superoxide dismutase, catalase, inducible NO synthase and interleukin-6 expression in dopaminergic cells under MPP+-induced oxidative stress. Oxid Med Cell Longev 2008;1(1):54-62.

Chavali SR, Forse RA. Decreased production of interleukin-6 and prostaglandin E2 associated with inhibition of delta5 desaturation of ω6 fatty acids in mice fed safflower oil diets supplemented with sesamol. J Nutr 1999;61(6):347-52.

How to Cite
1.
Khadem Haghighian M, Alipoor B, Malek Mahdavi A, Eftekhar Sadat B, Asghari Jafarabadi M, Moghaddam A. Effects of sesame seed supplementation on inflammatory factors and oxidative stress biomarkers in patients with knee osteoarthritis. Acta Med Iran. 53(4):207-213.
Section
Articles