Early Onset Hepatocellular Disease in an Infant with Zellweger Syndrome .

  • Mehri Najafi Sani Department of Pediatric Gastroenterology, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
  • Mitra Ahmadi Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
  • Pejman Roohani Department of Pediatric Gastroenterology, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
  • Nima Rezaei Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. َAND Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. AND 4Universal Scientific Education and Research Network (USERN), Tehran, Iran.
Keywords: Zellweger syndrome, Peroxisomal disorder, Micorcluplication

Abstract

Zellweger syndrome (ZS) is a peroxisomal disorder with a multiple congenital anomalies, characterized by stereotypical facies, profound hypotonia, organ involvement including cerebral, retinal, hepatic, and renal. Herein, a 3-month-old female with ZS is presented who was referred because of increased liver enzymes (subclinical hepatitis), which was detected in work-up of her neck cyst, severe hypotonia, and abnormal facies. An increased concentration of very long chain fatty acid in lipid profile was detected. ZS should be considered in the list of differential diagnosis in infants with stereotypical phenotype, neurodevelopmental delay, and severe hypotonia in association with liver and other organs involvement.

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Published
2015-10-27
How to Cite
1.
Najafi Sani M, Ahmadi M, Roohani P, Rezaei N. Early Onset Hepatocellular Disease in an Infant with Zellweger Syndrome . Acta Med Iran. 53(10):656-658.
Section
Case Report(s)