Study of Serum Uric Acid Levels in Myocardial Infarction and Its Association With Killip Class

  • Maryam Mehrpooya Department of Cardiology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
  • Farnoosh Larti Department of Cardiology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
  • Younes Nozari Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.
  • Roya Sattarzadeh-Badkoobeh Department of Cardiology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
  • Amir Farhang Zand Parsa Department of Cardiology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
  • Jayran Zebardast Department of Electronic Learning in Medical Education, Tehran University of Medical Sciences, Tehran, Iran.
  • Anahita Tavoosi Department of Cardiology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
  • Fatemeh Shahbazi Department of Biology, Payame Noor University, Tehran, Iran.
Keywords: Heart failure, Uric acid, Killip class, Myocardial infarction

Abstract

The present study aimed to compare the serum level of uric acid in patients with and without heart failure and also to determine the association between uric acid level and clinical status by Killip class in patients with STEMI. This case-control study was conducted on 50 consecutives as control group and 50 patients with acute heart failure, (20 patients had acute STEMI), who documented by both clinical conditions and echocardiography assessment. The mean plasma level of uric acid in the case group was 7.6±1.6 milligrams/deciliter (mg/dL) and in the control group was 4.5±1.5 respectively (P<0.001). These values in patients with STEMI was about 9.2±0.86, but in patients with acute heart failure in absence of STEMI was 6.5±1.04 (P<0.001). Moreover, there was significant difference among the level of uric acid and Killip classes (P<0.001). Also there was significant difference for uric acid level between HFrEF (HF with reduced EF) and severe LV systolic dysfunction (0.049). In STEMI patients with culprit LAD, mean uric acid was significantly higher than cases with culprit LCX [(9.7±0.98 versus 8.6±0.52 respectively) P=0.012]. Regarding  treatment plan in patients with STEMI, mean level of uric acid in those considered for CABG was significantly higher than who were considered for PCI, 9.9±0.82 versus 8.9±0.76 respectively, P=0.029. In STEMI patients with higher killip class, higher level of uric acid was seen. Also, the severity of LV systolic dysfunction was associated with higher level of uric acid.

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Published
2017-02-21
How to Cite
1.
Mehrpooya M, Larti F, Nozari Y, Sattarzadeh-Badkoobeh R, Zand Parsa AF, Zebardast J, Tavoosi A, Shahbazi F. Study of Serum Uric Acid Levels in Myocardial Infarction and Its Association With Killip Class. Acta Med Iran. 55(2):97-102.
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Articles