Acta Medica Iranica 2017. 55(4):254-258.

The Comparative Study of Ondansetron and Metoclopramide Effects in Reducing Nausea and Vomiting After Laparoscopic Cholecystectomy
Khatereh Isazadehfar, Masoud Entezariasl, Bita Shahbazzadegan, Zahra Nourani, Yousef Shafaee


Postoperative nausea and vomiting (PONV) are one of the most common complications of anesthesia and without prophylactic intervention occurs by about one-third of patients under general anesthesia. The aim of this study was to compare the efficacy of ondansetron and metoclopramide in reducing PONV after laparoscopic cholecystectomy. In this study, 60 patients undergoing laparoscopic cholecystectomy were randomly allocated into two equal groups (n=30), and in the first group 10 mg metoclopramide and in the second group 4 mg ondansetron preoperatively were injected. Nausea and vomiting and the need for rescue antiemetic treatment in recovery and 6 hr. and 6-24 hrs. After surgery were evaluated. Data were analyzed by SPSS software with chi-square test and analysis of variance (ANOVA). The incidence of nausea in metoclopramide was 43.3 % and in ondansetron was 33.3 %. The difference between two groups was not significant (P=0.6). The incidence of vomiting in metoclopramide was 20% and in ondansetron was 26.7%, and there was not any significant difference between intervention groups (P=0.12). For prevention of PONV after laparoscopic cholecystectomy, both metoclopramide and ondansetron are effective, and in preventing of nausea, ondansetron is more effective than metoclopramide, whereas there was not any significant difference between two drugs in preventing of vomiting.


Ondansetron; Metoclopramide; Laparoscopic cholecystectomy; PONV

Full Text:



Islam S, Jain PN. Post–operative nausea and vomiting (PONV): A Review Article. Indian J Anaesth 2004;48:253-8.

Entezariasl M, Khoshbaten M, Isazadehfar K, Akhavanakbari G. Efficacy of metoclopramide and dexamethasone for postoperative nausea and vomiting: a double-blind clinical trial. East Mediterr Health J 2010;16:300-3.

Loewen PS, Marra CA, Zed PJ. 5-HT3 receptor antagonists’ vs traditional agents for the prophylaxis of postoperative nausea and vomiting. Can J Anaesth 2000;47:1008-18.

Eidi M, Kolahdouzan Kh, Hosseinzadeh H, Tabaqi R. A Comparison of Preoperative Ondansetron and Dexamethasone in the Prevention of Post-Tympanoplasty Nausea and Vomiting. Iran J Med Sci 2012;37:166-72.

Habib AS, Gan TJ. Evidence-based management of postoperative nausea and vomiting: a review. Can J Anaesth 2004;51:326-41.

Park A, Lee G, Seagull FJ, Meenaghan N, Dexter D. Patients benefit while surgeons suffer: an impending epidemic. J Am Coll Surg 2010;210:306-13.

Sarkar M, Sarkar A, Dewoolkar L, Charan S.Comparative study of single dose intravenous ondansetron and metoclopromide as premedication for prevention of postoperative nausea and vomiting in obstetrical laparoscopic surgery under general anesthesia. Internet J Anaesthesiol 2007;13:(2).

Gautam B, Shrestha BR, Lama P, Rai S. Antiemetic prophylaxis against postoperative nausea and vomiting with ondansetron-dexamethasone combination compared to ondansetron or dexamethasone alone for patients undergoing laparoscopic cholecystectomy. Kathmandu Univ Med J 2008;6:319-28.

Gupta V, Wakhloo R, Mahta MK, Gupta SD.Prophylactic Antiemetic Therapy with Ondansetron, Granisetron and Metoclopramide in Patients Undergoing Laparoscopic Cholecystectomy Under General Anaesthesia. J Med Edu Res 2008;10:74-7.

Kaki MA, EL-Hakeem EE. Prophylaxis of postoperative nausea and vomiting with ondansetron, metoclopramide or placebo in total intravenous anesthesia patients undergoing laparoscopic cholecystectomy. Saudi Med J 2008;29:1408-13

Sandhu T, Tanvatcharaphan P, Cheunjongkolkul V.Ondansetron versus metoclopramide in prophylaxis of nausea and vomiting for laparoscopic cholecystectomy: a prospective double-blind randomized study. Asian J Surg 2008;31:50-4.

Helmy SAK. Prophylactic anti-emetic efficacy of ondansetron in laparascopic cholecystectomy under total intravenous anaesthesia. A ramdomised, doubleblind comparison with droperidol, metoclopramide and placebo. Anaesthesia 1999;54:266-96.

Wilson EB, Bass CS, Abrameit W, Roberson R, Smith RW. Metoclopramide versus ondansetron in prophylaxis of nausea and vomiting for laparoscopic cholecystectomy. Am J Surg 2001;181:138-41.

Yeasmeen S, Yasmin R, Akhtaruzzaman A, Shahera Khatun U. Intravenous Granisetron, Ondansetron and Metoclopramide in the Prevention and Treatment of Postoperative Nausea and Vomiting after Laparoscopic Cholecystectomy - A Comparative Study. J BSA 2006;19:20-7.

Monagle J, Barnes R, Goodchild C, Hewitt M.Ondansetron is not superior to moderate dose metoclopramide in the prevention of post-operative nausea and vomiting after minor gynaecological surgery. Eur J Anaesthesiol 1997;14:604-9.

Silva AC, O'Ryan F, Poor DB. Postoperative nausea and vomiting (PONV) after orthognathic surgery: a retrospective study and literature review. J Oral Maxillofac Surg 2006;64:1385-97.

Kushwaha B, Chakraborty A, Agarwal J, Malick A, Bhushan S, Bhattacharya P. Comparative study of granisetron and ondansetron alone and their combination with dexamethasone, for prevention of PONV in middle ear surgery. Internet J Anesthesiol 2007;13:(2).


  • There are currently no refbacks.

Creative Commons Attribution-NonCommercial 3.0

This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.