Acta Medica Iranica 2017. 55(5):324-332.

Effects of Inhaled Salbutamol on Sport-Specific Fitness of Non-Asthmatic Football Players
Farzin Halabchi, Mahdi Abarashi, Mohammad Ali Mansournia, Tohid Seifbarghi


In this article, we investigated the effectiveness of inhaled salbutamol withtherapeutic dose on the sport-specific performance of non-asthmatic young football players. In a double-blinded, randomised placebo controlled trial with 2-treatment, 2-period crossover design, twenty participants who were non-asthmatic junior professional football players were randomly allocated to two groups. Fifteen minutes before sport-specific fitness testing, each group randomly received 2 inhalations (200 micrograms) of salbutamol or placebo, respectively. After 1 week wash-out period, each participant has tested again, this time with the alternative inhaler. The primary outcomes were the differences between salbutamol and placebo groups in six tests of 7×30-m repeated sprint, Loughborough soccer dribbling, vertical jump, agility, Loughborough soccer passing, 20-m multistage shuttle run. A total of twenty players did two test batteries completely. There was no significant difference between salbutamol and placebo users in the tests [Treatment effect (CI95%); 7×30 sprint: -2.4 (-7.6-2.9), dribbling: -3.8 (-12.2-4.5), vertical jump: -1.2 (-3.7-1.3), agility: -0.4 (-0.9-0.1), passing: 0.2 (-12-12.4), shuttle run distance: -112 (-503.2-279.2)]. Furthermore, no period or carry-over effects were detected. It seems that single therapeutic dose of inhaled salbutamol (200 micrograms) does not appear to improve football related performance.


Performance; Beta-agonist; Doping; Football; Soccer; Conditioning

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Carlsen KH, Anderson SD, Bjermer L, Bonini S, Brusasco V, Canonica W, et al. Exercise-induced asthma, respiratory and allergic disorders in elite athletes: epidemiology, mechanisms and diagnosis: part I of the report from the Joint Task Force of the European Respiratory Society (ERS) and the European Academy of Allergy and Clinical Immunology (EAACI) in cooperation with GA2LEN. Allergy. 2008;63:387-403.

Bangsbo J. The physiology of soccer--with special reference to intense intermittent exercise. Acta Physiol Scand Suppl. 1994;619:1-155.

Stølen T, Chamari K, Castagna C, Wisløff U. Physiology of soccer. Sports medicine. 2005;35:501-36.

Sødal A. Bronchial hyperreactivity, exercise induced asthma and allergy. A study of female national team athletes in soccer Norwegian University of Sport and Physical Education. 1997.

Beck KC, Joyner MJ, Scanlon PD. Exercise-induced asthma. Exercise and Sport Sciences Reviews. 2002;30:1-3.

Fitch KD. beta2-Agonists at the Olympic Games. Clin Rev Allergy Immunol. 2006;31:259-68.

Wolfarth B, Wuestenfeld JC, Kindermann W. Ergogenic effects of inhaled beta2-agonists in non-asthmatic athletes. Endocrinol Metab Clin North Am. 2010;39:75-87, ix.

Pluim BM, de Hon O, Staal JB, Limpens J, Kuipers H, Overbeek SE, et al. beta(2)-Agonists and physical performance: a systematic review and meta-analysis of randomized controlled trials. Sports Med. 2011;41:39-57.

WADA. The World Anti-Doping Code. The 2011 Prohibited list. 2011.

Dvorak J, Graf-Baumann T, D'Hooghe M, Kirkendall D, Taennler H, Saugy M. FIFA's approach to doping in football. Br J Sports Med. 2006;40 Suppl 1:i3-i12.

Dvorak J, McCrory P, D’Hooghe M. FIFA’s future activities in the fight against doping. British Journal of Sports Medicine. 2006;40:i58-i9.

Sporer BC, Sheel AW, McKenzie DC. Dose response of inhaled salbutamol on exercise performance and urine concentrations. Med Sci Sports Exerc. 2008;40:149-57.

Moher D, Hopewell S, Schulz KF, Montori V, Gøtzsche PC, Devereaux P, et al. CONSORT 2010 explanation and elaboration: updated guidelines for reporting parallel group randomised trials. Journal of clinical epidemiology. 2010;63:e1-e37.

Kirkendall DT, Leiper JB, Bartagi Z, Dvorak J, Zerguini Y. The influence of Ramadan on physical performance measures in young Muslim footballers. J Sports Sci. 2008;26 Suppl 3:S15-27.

Krustrup P, Mohr M, Steensberg A, Bencke J, Kjær M, Bangsbo J. Muscle and blood metabolites during a soccer game: implications for sprint performance. Medicine and science in sports and exercise. 2006;38:1165-74.

Spencer M, Fitzsimons M, Dawson B, Bishop D, Goodman C. Reliability of a repeated-sprint test for field-hockey. J Sci Med Sport. 2006;9:181-4.

Ali A. Measuring soccer skill performance: a review. Scand J Med Sci Sports. 2011;21:170-83.

McGregor S, Nicholas C, Lakomy H, Williams C. The influence of intermittent high-intensity shuttle running and fluid ingestion on the performance of a soccer skill. Journal of sports sciences. 1999;17:895-903.

Klavora P. Vertical-jump tests: A critical review. Strength & Conditioning Journal. 2000;22:70.

Markovic G, Dizdar D, Jukic I, Cardinale M. Reliability and factorial validity of squat and countermovement jump tests. The Journal of Strength & Conditioning Research. 2004;18:551-5.

Sargent DA. The physical test of a man. American Physical Education Review. 1921;26:188-94.

Rösch D, Hodgson R, Peterson L, Graf-Baumann T, Junge A, Chomiak J, et al. Assessment and evaluation of football performance. The American Journal of Sports Medicine. 2000;28:S-29-S-39.

Ali A, Williams C, Hulse M, Strudwick A, Reddin J, Howarth L, et al. Reliability and validity of two tests of soccer skill. J Sports Sci. 2007;25:1461-70.

Leger L, Mercier D, Gadoury C, Lambert J. The multistage 20 metre shuttle run test for aerobic fitness. Journal of sports sciences. 1988;6:93-101.

Léger LA, Lambert J. A maximal multistage 20-m shuttle run test to predict dot VO2 max. European journal of applied physiology and occupational physiology. 1982;49:1-12.

Jones B, Kenward MG. Design and analysis of cross-over trials: CRC Press; 2003.

van Baak MA, de Hon OM, Hartgens F, Kuipers H. Inhaled salbutamol and endurance cycling performance in non-asthmatic athletes. Int J Sports Med. 2004;25:533-8.

Goubault C, Perault MC, Leleu E, Bouquet S, Legros P, Vandel B, et al. Effects of inhaled salbutamol in exercising non-asthmatic athletes. Thorax. 2001;56:675-9.

Andersen K, Kanstrup I-L. Effects of acute oral administration of 4 mg salbutamol on exercise performance in non-asthmatic elite athletes. JEPonline. 2009;12:36-49.

Bedi JF, Gong H, Jr., Horvath SM. Enhancement of exercise performance with inhaled albuterol. Can J Sport Sci. 1988;13:144-8.

Carlsen KH, Ingjer F, Kirkegaard H, Thyness B. The effect of inhaled salbutamol and salmeterol on lung function and endurance performance in healthy well-trained athletes. Scand J Med Sci Sports. 1997;7:160-5.

Heir T, Stemshaug H. Salbutamol and high-intensity treadmill running in nonasthmatic highly conditioned athletes. Scand J Med Sci Sports. 1995;5:231-6.

Fleck SJ, Lucia A, Storms WW, Wallach JM, Vint PF, Zimmerman SD. Effects of acute inhalation of albuterol on submaximal and maximal VO2 and blood lactate. Int J Sports Med. 1993;14:239-43.

Lemmer JT, Fleck SJ, Wallach JM, Fox S, Burke ER, Kearney JT, et al. The effects of albuterol on power output in non-asthmatic athletes. Int J Sports Med. 1995;16:243-9.

McDowell SL, Fleck SJ, Storms WW. The effects of salmeterol on power output in nonasthmatic athletes. J Allergy Clin Immunol. 1997;99:443-9.

Meeuwisse WH, McKenzie DC, Hopkins SR, Road JD. The effect of salbutamol on performance in elite nonasthmatic athletes. Med Sci Sports Exerc. 1992;24:1161-6.

Morton AR, Joyce K, Papalia SM, Carroll NG, Fitch KD. Is salmeterol ergogenic? Clinical Journal of Sport Medicine. 1996;6:220-5.

Norris SR, Petersen SR, Jones RL. The effect of salbutamol on performance in endurance cyclists. Eur J Appl Physiol Occup Physiol. 1996;73:364-8.

Larsson K, Gavhed D, Larsson L, Holmer I, Jorfelt L, Ohlsen P. Influence of a beta2-agonist on physical performance at low temperature in elite athletes. Med Sci Sports Exerc. 1997;29:1631-6.

Sandsund M, Sue-Chu M, Helgerud J, Reinertsen RE, Bjermer L. Effect of cold exposure (-15 degrees C) and salbutamol treatment on physical performance in elite nonasthmatic cross-country skiers. Eur J Appl Physiol Occup Physiol. 1998;77:297-304.

Sue-Chu M, Sandsund M, Helgerud J, Reinertsen RE, Bjermer L. Salmeterol and physical performance at -15 degrees C in highly trained nonasthmatic cross-country skiers. Scand J Med Sci Sports. 1999;9:48-52.

McKenzie DC, Rhodes EC, Stirling DR, Wiley JP, Dunwoody DW, Filsinger IB, et al. Salbutamol and treadmill performance in non-atopic athletes. Med Sci Sports Exerc. 1983;15:520-2.

Morton AR, Papalia SM, Fitch KD. Is Salbutamol Ergogenic?: the Effects of Salbutamol on Physical Performance in High-Performance Nonasthmatic Athletes. Clinical Journal of Sport Medicine. 1992;2:93-7.

Morton AR, Papalia SM, Fitch KD. Changes in Anaerobic Power and Strength Performance After Inhalation of Salbutamol in Nonasthmatic Athletes. Clinical Journal of Sport Medicine. 1993;3:14-9.

Signorile JF, Kaplan TA, Applegate B, Perry AC. Effects of acute inhalation of the bronchodilator, albuterol, on power output. Med Sci Sports Exerc. 1992;24:638-42.

Hu J, Dickinson J, Chester N, Drust B, Whyte G, Loosemoore M. The effect of 800 μg and 1600 μg inhaled salbutamol on FEV1 in non-asthmatic football players. British Journal of Sports Medicine. 2011;45:A20-A.

Dickinson J, Hu J, Chester N, Loosemore M, Whyte G. The Impact of Inhaled Salbutamol on Repeated Sprint Ability in Pre-Fatigued Soccer Players. J Sports Med Doping Stud. 2015;5:2161-0673.100016.

Dickinson J, Hu J, Chester N, Loosemore M, Whyte G. Acute impact of inhaled short acting b2-agonists on 5 km running performance. J Sports Sci Med. 2014;13:271-9.


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