Acta Medica Iranica 2016. 54(10):683-685.

Adult Onset Still's Disease With Different Antibodies: A Case Report and Review of Literature
Maryam Mobini, Roya Ghasemian, Fatemeh Zameni

Abstract


 Adult-onset Still’s disease (AOSD) is a rare systemic inflammatory disorder of unknown etiology. There is not currently any specific serological markers for AOSD , and  diagnosis still relying on the exclusion of other likely diagnoses. Yamaguchi’s criteria are used as a diagnostic criterion which contains negative serologic markers for other collagen vascular diseases including systemic lupus erythematosus and rheumatoid arthritis. Here we report a 28-year-old woman with arthralgia, fever, rash, leukocytosis, lymphadenopathy, sore throat, abnormal liver function and negative rheumatoid factor and ANA but  seropositive for anti-CCP, anti-dsDNA, and C-ANCA. It seems that despite AOSD is considered as a seronegativedisorder; it should be remembered in patients with compatible findings who are seropositive.

Keywords


Adult-onset Still’s disease; Polyarthralgia; ANCA; Anti CCP; Anti-dsDNA

Full Text:

PDF

References


Iliou C, Papagoras C, Tsifetaki N, Voulgari PV, Drosos AA. Adult-onset Still's disease: clinical, serological and therapeutic considerations.ClinExpRheumatol 2013;31:47-52.

Cozzi A, Papagrigoraki A, Biasi D, Colato C, Girolomoni G. Cutaneousmanifestations of adult-onset Still’s disease: a case report and review of theliterature. ClinRheumatol2016;35:1377-82.

Yamaguchi M, Ohta A, Tsunematsu T, Kasukawa R, Mizushima Y, Kashiwagi H, et al. Preliminary criteria for theclassification of adult Still’s disease. J Rheumatol 1992;19:424-30.

Saghafi M, Sahebari M. Does searching for Antineutrophil cytoplasmic antibodies helpwith the diagnosis of Adult- onset Still’s Disease? RheumatolInt 2013;33:571-4.

Ichida H, Kawaguchi Y, Sugiura T, Takagi K, Katsumata Y, Gono T, et al. Clinical manifestations of adult-onset still's disease presenting with erosive arthritis: Association with low levels of ferritin and IL-18. Arthritis Care Res2014;66:642-6.

Riera E, Olivé A, Narváez J, Holgado S, Santo P, Mateo L, et al. Adult onset Still's disease: review of 41 cases. Clin Exp Rheumatol 2011;29:331-6.

Reddy Munagala VV, Misra R, Agarwal V, Lawrence A, Aggarwal A. Adult onsetStill's disease: experience from a tertiary care rheumatology unit.Int J Rheum Dis 2012;15:e136-41.

Qinjin H ,Zhencheng Y, Jian Z. Adult-onset Still’s disease:how to make a diagnosis in an atypical case. RheumatolInt2012;32:3299-302.

Toshiyuki Y. Cutaneous manifestations associated with adult-onset Still’s disease: important diagnostic values. RheumatolInt 2012;32:2233-7.


Refbacks

  • There are currently no refbacks.


Creative Commons Attribution-NonCommercial 3.0

This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.