Adult Onset Still's Disease With Different Antibodies: A Case Report and Review of Literature

  • Maryam Mobini Department of Rheumatology, Diabetes Research Center, Mazandaran University of Medical Sciences, Mazandaran, Iran.
  • Roya Ghasemian Department of Infectious Diseases, Antimicrobial Resistance Research Center, Mazandaran University of Medical Sciences, Mazandaran, Iran.
  • Fatemeh Zameni Department of Infectious Diseases, Antimicrobial Resistance Research Center, Mazandaran University of Medical Sciences, Mazandaran, Iran.
Keywords: Adult-onset Still’s disease, Polyarthralgia, ANCA, Anti CCP, Anti-dsDNA

Abstract

 Adult-onset Still’s disease (AOSD) is a rare systemic inflammatory disorder of unknown etiology. There is not currently any specific serological markers for AOSD , and  diagnosis still relying on the exclusion of other likely diagnoses. Yamaguchi’s criteria are used as a diagnostic criterion which contains negative serologic markers for other collagen vascular diseases including systemic lupus erythematosus and rheumatoid arthritis. Here we report a 28-year-old woman with arthralgia, fever, rash, leukocytosis, lymphadenopathy, sore throat, abnormal liver function and negative rheumatoid factor and ANA but  seropositive for anti-CCP, anti-dsDNA, and C-ANCA. It seems that despite AOSD is considered as a seronegativedisorder; it should be remembered in patients with compatible findings who are seropositive.

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Published
2016-11-19
How to Cite
1.
Mobini M, Ghasemian R, Zameni F. Adult Onset Still’s Disease With Different Antibodies: A Case Report and Review of Literature. Acta Med Iran. 54(10):683-685.
Section
Case Report(s)