Acta Medica Iranica 2018. 56(4):267-271.

Thyroid Function Status and Thyroid Hormones Disturbances in Polycystic Ovarian Syndrome
Alireza Abdollahi, Manouchehr Nakhjavani, Farnaz Sohrabvand

Abstract


A close association between thyroid problems and polycystic ovarian syndrome (PCOS) has been recently raised suggesting common pathophysiological link between the two disease conditions. The present study aimed to assess the status of thyroid hormones in women with PCOS with the aim of clarifying the link between PCOS and thyroid abnormalities. This cross-sectional study was performed on 87 consecutive women aged 31 to 50 years finally diagnosed as PCOS based on the Rotterdam diagnostic criteria. Venous blood sample was extracted from all subjects to determine the levels of fasting blood glucose, hemoglobin A1C, serum insulin level and also thyroid hormones in a single laboratory. The mean serum level of TSH was 3.02±1.19 µIU/ml, the mean level of T4 was 7.22±1.81 µg/dl, and the mean level of T3 was 1.23±0.18 ng/ml. Based on the normal values of thyroid hormones, none of the PCOS patients had abnormal levels of TSH and T3 hormones. Also, normal level of T4 was revealed in 90.8% of patients, while only 6.9% and 2.3% had T4 level lower than and higher than the normal range respectively. Using the correlation tests, none of the thyroid hormones was linearly associated with age, weight, BMI, the value of FBS or the levels of lipid profiles. The high prevalence rate of overweight to obesity (97.7%), hypertriglyceridemia (65.5%), and uncontrolled glycemic status (21.8%) were prominent in PCOS women. In our observation, we found no significant link between abnormal changes in thyroid hormone and PCOS.


Keywords


Thyroid gland; Thyroid hormones; Polycystic ovarian syndrome

Full Text:

PDF

References


Sirmans SM, Pate KA. Epidemiology, diagnosis, and management of polycystic ovary syndrome. Clin Epidemiol 2013;6:1-13.

Jalilian A, Kiani F, Sayehmiri F, Sayehmiri K, Khodaee Z, Akbari M. Prevalence of polycystic ovary syndrome and its associated complications in Iranian women: A meta-analysis. Iran J Reprod Med 2015;13:591-604.

Glintborg D. Endocrine and metabolic characteristics in polycystic ovary syndrome. Dan Med J 2016;63:B5232.

Kyaw Tun T, McGowan A, Phelan N, Correia N, Boran G, O'Connor AL, et al. Obesity and Insulin Resistance Are the Main Determinants of Postprandial Lipoprotein Dysmetabolism in Polycystic Ovary Syndrome. Int J Endocrinol 2016;2016:9545239.

Gul OO, Cander S, Gul B, Açıkgoz E, Sarandol E, Ersoy C. Evaluation of insulin resistance and plasma levels for visfatin and resistin in obese and non-obese patients with polycystic ovary syndrome. Eur Cytokine Netw 2015;26:73-8.

Ozegowska K, Pawelczyk L. Cardiometabolic risk in patients with polycystic ovary syndrome. Ginekol Pol 2015;86:840-8.

Charalampakis V, Tahrani AA, Helmy A, Gupta JK, Singhal R. Polycystic ovary syndrome and endometrial hyperplasia: an overview of the role of bariatric surgery in female fertility. Eur J Obstet Gynecol Reprod Biol 2016;207:220-6.

Lauretta R, Lanzolla G, Vici P, Mariani L, Moretti C, Appetecchia M. Insulin-Sensitizers, Polycystic Ovary Syndrome and Gynaecological Cancer Risk. Int J Endocrinol 2016;2016:8671762.

Goodman NF, Cobin RH, Futterweit W, Glueck JS, Legro RS, Carmina E. American Association of Clinical Endocrinologists, American College of Endocrinology, and Androgen Excess and PCOS Society Disease State Clinical Review: Guide to the Best Practicees in the Evslustion and Treatment of Polycystic Ovary Syndrome--PART 1. Endocr Pract 2015;21:1291-300.

Conway G, Dewailly D, Diamanti-Kandarakis E, Escobar Morreale HF, Franks S, Gambineri A, et al. ESE PCOS Special Interest Group.. European survey of diagnosis and management of the polycystic ovary syndrome: results of the ESE PCOS Special Interest Group's Questionnaire. Eur J Endocrinol 2014;171:489-98.

Inan C, Karadag C. Correlation between ovarian morphology and biochemical and hormonal parameters in polycystic ovary syndrome. Pak J Med Sci 2016;32:742-5.

Polat SB, Oğuz O, Sacikara M, Cuhaci FN, Evranos B, Ersoy R, et al. Thyroid Disorders in Young Females with Polycystic Ovary Syndrome and Correlation of Thyroid Volume with Certain Hormonal Parameters. J Reprod Med 2016;61:27-32.

Novais Jde S, Benetti-Pinto CL, Garmes HM, Jales RM, Juliato CR. Polycystic ovary syndrome and chronic autoimmune thyroiditis. Gynecol Endocrinol 2015;31:48-51.

Sahin M, Demircioglu D, Oguz A, Tuzun D, Sarica MA, Inanc E, et al. Does insulin resistance increase thyroid volume in patients with polycystic ovary syndrome? Arch Endocrinol Metab 2016;61:145-51.

Muderris II, Boztosun A, Oner G, Bayram F. Effect of thyroid hormone replacement therapy on ovarian volume and androgen hormones in patients with untreated primary

hypothyroidism. Ann Saudi Med 2011;31:145-51.

Sinha U, Sinharay K, Saha S, Longkumer TA, Baul SN, Pal SK. Thyroid disorders in polycystic ovarian syndrome subjects: A tertiary hospital based cross-sectionalstudy from Eastern India. Indian J Endocrinol Metab 2013;17:304-9.

Du D, Li X. The relationship between thyroiditis and polycystic ovary syndrome: a meta-analysis. Int J Clin Exp Med 2013;6:880-9.

Hollowell JG, Staehling NW, Flanders WD, Hannon WH, Gunter EW, Spencer CA, et al. Serum TSH, T4, and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). Journal of Clinical Endocrinology and Metabolism 2002:87;489-99.

Muderris II, Boztosun A, Oner G, Bayram F. Effect of thyroid hormone replacement therapy on ovarian volume and androgen hormones in patients with untreated primary hypothyroidism. Ann Saudi Med 2011;31:145-51.

Dittrich R, Kajaia N, Cupisti S, Hoffmann I, Beckmann MW, Mueller A. Association of thyroid-stimulating hormone with insulin resistance and androgen parameters in women with PCOS. Reprod Biomed Online 2009;19:319-25.


Refbacks

  • There are currently no refbacks.


Creative Commons Attribution-NonCommercial 3.0

This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.