Correlation of Immunohistochemical Expression of CXCR4 With Clinicopathological Characteristics of Invasive Ductal Carcinoma of Breast

  • Anahita Nosrati Department of Pathology, Gastrointestinal Cancer Research Center, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, Iran.
  • Zhila Torabizadeh Department of Pathology, Gut and Liver Research Center, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, Iran.
  • Mahboobeh Majlesi Department of Pathology, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, Iran.
Keywords: Breast, Invasive ductal carcinoma, CXCR4, Clinicopathologic characteristics, Immunohistochemistry


 Breast cancer is the most frequent malignancy among women worldwide including Iranian women. The different markers have already been investigated for predicting invasion and metastases which one of the most tempting ones is Chemokines. In fact, one of the well-known mediators in the breast cancer metastases is stromal cell-derived factor-1 (SDF-1) CXCR4 chemokine. The CXCR4 chemokine receptor is a G-protein-coupled receptor that selectively binds to SFD-1 (also known as CXCL12). It is obvious that this chemokine receptor plays a critical role in some biologic processes. Nevertheless, there is not enough study to confirm the CXCR4 clinical importance and also its exact prognostic worth in the breast cancer. We carried out this diagnostic study. Immunohistochemically on 70 paraffin blocks of invasive ductal breast carcinoma and adjacent normal tissue simultaneously to assess the expression of CXCR4. The correlation between the presence and intensity of expression of this marker with various clinicopathological factors including age, tumor size, lymph node involvement, stage, and grade are evaluated in all patients. Among the 70 cases, 64 cancer specimens (91.4%) showed CXCR4 expression. It is found out that there is a significant difference between the expression of CXCR4 and the histological grade and lymph node metastasis (P<0.001), but no correlation with other clinicopathologic parameters, such as age, tumor size, and the stage is identified. By considering the CXCR4 intensity, we came across a significant difference between the high expression and the size, stage, histological grade and lymph node metastasis (P<0.001). Breast cancer is the most common invasive tumor to afflict women through the world. According to our study, there is a significant relationship between the expression of CXCR4 and grade, lymph node metastasis in the breast cancer. Furthermore, there is a direct significant correlation between the intensity of expression with grade, stage, tumor size, and lymph node metastasis. Thus, it can be used as a predictor factor for the breast cancer.


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How to Cite
Nosrati A, Torabizadeh Z, Majlesi M. Correlation of Immunohistochemical Expression of CXCR4 With Clinicopathological Characteristics of Invasive Ductal Carcinoma of Breast. Acta Med Iran. 56(6):366-371.