Acta Medica Iranica 2018. 56(8):508-515.

Vitamin D Level and Vitamin D Receptor Gene Polymorphisms in Iranian Azeri Turkish Patients With Autoimmune Thyroid Diseases
Amir Hossein Faghfouri, Morteza Bagheri, Alireza Mehdizadeh, Parvin Ayremlou, Rasoul Zarrin


The Autoimmune thyroid diseases (AITDs) are among the most common endocrine disorders. Vitamin D as an immunomodulator and Vitamin D receptor (VDR) gene polymorphisms may be effective in AITDs pathogenesis. The aim of this study was to evaluate the vitamin D level and VDR BsmI and TaqI polymorphisms in Iranian Azeri Turkish patients with AITDs. This case-control study included 121 adults with AITDs and 117 non-AITDs controls. Serum level of 25-hydroxyvitamin D was measured by electrochemiluminescence (ECL) immunoassay. BsmI and TaqI polymorphisms were assessed by polymerase chain reaction fragment length polymorphism technique. The serum level of 25-hydroxyvitamin D in AITDs patients were lower than controls (P=0.03). The frequencies of TT, TC, CC, T and C genotypes/alleles at TaqI (rs731236) marker were 52.1%, 34.7%, 13.2% , 69.4% and 30.6% in AITDs and 44.4%, 41.9%, 13.7%, 65.4% and 34.6% in controls, respectively. The frequencies of AA, AG, GG, A and G genotypes/alleles at BsmI (rs1544410) marker were 14%, 64.5%, 21.5% , 46.3% and 53.7% in AITDs and 26.5%, 58.1%, 15.4%, 55.6% and 44.4% in controls, respectively. BsmI (rs1544410) GG+AG genotypes and G allele were more frequent among patients with Hashimoto compared with control group (86.6% vs. 73.5% (OR: 2.34, 95% CI: 1.16-4.70, P = 0.014) and 54.29% vs. 44.44% (OR: 1.48, 95% CI: 1.02-2.15, P = 0.038), respectively). Vitamin D status can be related to AITDs pathogenesis. BsmI (rs1544410) GG+AG genotypes and G allele may play an important role in the predisposition to Hashimoto. 


Hashimoto disease, Graves disease, Vitamin D receptor, Polymorphism, Vitamin D level

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