Mitochondrial Dysfunction in Multiple Sclerosis: A Systematic Review

  • Alia Saberi Neuroscience Research Center, Department of Neurology, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran.
  • Samaneh Kazemi Deputy of Research and Technology, Guilan University of Medical Sciences, Rasht, Iran.
Keywords: Multiple sclerosis, Disease progression, DNA, Mitochondria


Multiple sclerosis (MS) is a chronic inflammatory demyelinating disorder of the central nervous system (CNS) and is characterized by a high degree of heterogeneity in progression and treatment response. Mitochondrial dysfunction is increasingly recognized as an important feature of MS pathology and may be relevant for clinical disease progression. This paper systematically reviews published evidence concerning the role of mitochondrial abnormalities with MS. Literature searched using the Web of Science, PMC/Medline via PubMed and Scopus databases up to May 2017 with no time and language limitation. After quality assessment, 9 articles were included in the study. All data extraction was conducted by two reviewers independently. Based on the results of the studies, it seems that mitochondrial DNA abnormality and mitochondrial dysfunction may be due to primary inflammation in MS or may be occurred itself before any inflammation, but definitely contributes to axonal degeneration and disease progression. Mitochondrial abnormality contributes to axonal degeneration in MS and disease progression.


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How to Cite
Saberi A, Kazemi S. Mitochondrial Dysfunction in Multiple Sclerosis: A Systematic Review. Acta Med Iran. 57(1):5-16.
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