Effect of Radiation Therapy on Wound Healing

  • Gashtasb Aghasinejad Chemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
  • Mehdi Raei Baqiyatallah Research Center for Gastroenterology and Liver Diseases (BRCGL), Baqiyatallah University of Medical Sciences, Tehran, Iran. AND Department of Epidemiology and Biostatistics, Faculty of Health, Baqiyatallah University of Medical Sciences, Tehran, Iran.
  • Saeid Azad Cellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran.
  • Bahareh Aghasinejad Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Keywords: Wound healing, Radiation therapy, Skin, Mice

Abstract

Many studies were carried out to improve sophisticated approaches to accelerate wound healing processes and also, wound healing is extensively discussed in the medicinal literature. In this study, we aimed to investigate the wound healing of mice with visible radiation (630 nm). In this study, 28 male mice were used and randomly divided into 4 groups. All samples were subjected to a 6 mm skin incision. Four groups were tested as following 10 minutes (First group), 20 minutes (Second group), 30 minutes (Third group) light exposure and no light radiation (control group), respectively. Wound contraction was analyzed by taking photos and Image J software. All mice were sacrificed, and samples were evaluated by Hematoxylin and Eosin staining after one week. The results demonstrated that the experimental group with 20 min.light irradiation had a much faster effect of wound healing than the 10, 30 minute and control group. The results showed that 20 minutes of light exposure group was the best treatment.

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Published
2019-05-13
How to Cite
1.
Aghasinejad G, Raei M, Azad S, Aghasinejad B. Effect of Radiation Therapy on Wound Healing. Acta Med Iran. 57(3):167-172.
Section
Articles