Comparison of Ten-Day Sequential and Standard Triple Therapy for Helicobacter pylori Eradication

  • Behdad Ravarian Department of Internal Medicine, AJA University of Medical Sciences, Tehran, Iran.
  • Abbas Esmaeilzadeh Department of Gastroenterology and Hepatology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Sandra Saeedi Department of Internal Medicine, AJA University of Medical Sciences, Tehran, Iran.
  • Meysam Moghbeli Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Azita Ganji Department of Gastroenterology and Hepatology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Keywords: Helicobacter pylori, Clarithromycin, Amoxicillin, Proton pump inhibitors

Abstract

Helicobacter pylori (HBP) is reported as one of the main causes of peptic ulcer disease (PUD) and gastric cancer in the world. The challenge for finding an optimal treatment regimen for HBP eradication is still a matter of concern. The aim of this study was to compare the HBP eradication rate as well as side effects between two 10-days treatments of the standard triple and sequential regimen. This study was performed on patients with dyspepsia and HBP positive. Patients were categorized in two treatment groups including; standard (Omeprazole, Amoxicillin, and Clarithromycin) and sequential treatment (Omeprazole, Amoxicillin, Clarithromycin, and Metronidazole). HBP eradication rate, side effects, and treatment costs were compared between two groups. One hundred thirty-two patients (58 males, 74 females) with a mean age of 42.7±14.2-year-old were studied in two groups of Standard Treatment (n=66) and Sequential Treatment (n=66). There were not any significant differences between two groups regarding baseline features. The overall rate of HBP eradication was estimated to be 79.5%. Although, there was not any significant difference between the observed side effects, the mean cost of treatment in standard was significantly lower than that in the sequential group (P=0.001). It seems that there are not any clinical differences between 10-day treatment plan of the standard triple and sequential therapy in the case of HBP eradication and side effects. However, the sequential treatment might be a better option as the economic point of view.

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Published
2019-07-15
How to Cite
1.
Ravarian B, Esmaeilzadeh A, Saeedi S, Moghbeli M, Ganji A. Comparison of Ten-Day Sequential and Standard Triple Therapy for Helicobacter pylori Eradication. Acta Med Iran. 57(4).
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Articles