Case Report

A Subcutaneous Pleomorphic Hyalinizing Angiectatic Tumor of Soft Parts of the Right Ankle: A Case Report

Abstract

Pleomorphic hyalinizing angiectatic tumor (PHAT) is a rare, slow-growing mass, which is locally aggressive and classified as tumors of borderline malignancy. In this study, we report a case of subcutaneous ankle mass in 43-year-old female since 2 years ago with a pathological diagnosis of PHAT, characterized by clusters of ectatic, fibrin-lined, and thin-walled vessels which are surrounded by a spindled or pleomorphic neoplastic stroma.

Matsumoto K, Yamamoto T. Pleomorphic hyalinizing angiectatic tumor of soft parts: a case report and literature review. Pathol Int 2002; 52: 664-8.

Fujiwara M, Yuba Y, Wada A, Ozawa T, Tanaka T.

Pleomorphic hyalinizing angiectatic tumor of soft parts: report of a case and review of the literature. J Dermatol 2004; 31:19-23.

El-Tal AE, Mehregan D. Pleomorphic hyalinizing angiectatic tumor of soft parts: case report and literature review. J Cutan Pathol 2006; 33: 361-4.

Ke Q, Erbolat, Zhang HY, Bu H, Li S, Shi DN, Yang GH, Chen HJ, Wei B. Clinicopathologic features of pleomorphic hyalinizing angiectatic tumor of soft parts. Chin Med J (Engl) 2007; 120: 876-81.

Fletcher CDM, Bridge JA, Hogendoorn PCW, Mertens F. World health organization classifction of tumors of soft tissue and bone. pathology and genetics of tumors of soft tissue and bone. Lyon: IARC Press; 2013.

Smith ME, Fisher C, Weiss SW. Pleomorphic hyalinizing

angiectatic tumor of soft parts. A low-grade neoplasm resembling neurilemoma. Am J Surg Pathol 1996;20:21–9

Labanaris AP, Zugor V, Witt JH, Kühn R.Pleomorphic hyalinizing angiectatic tumor of the scrotum. Urol J 2011; 8: 248-50.

Illueca C, Machado I, Cruz J, Almenar S, Noguera R, Navarro S, Llombart-Bosch A. Pleomorphic hyalinizing angiectatic tumor: a report of 3 new cases, 1 with sarcomatous myxofbrosarcoma component and another with unreported soft tissue palpebral location. Appl Immunohistochem Mol Morphol 2012; 20: 96-101.

Wei S, Pan Z, Siegal GP, Winokur TS, Carroll AJ, Jhala D. Complex analysis of a recurrent pleomorphic hyalinizing angiectatic tumor of soft parts. Hum Pathol 2012; 43: 121-6.

Idrees MT, Kieffer T, Badve S. Pleomorphic hyalinizing angiectatic tumor of renal hilum. Ann Diagn Pathol 2012; 16: 489-93.

Suzuki K, Yasuda T, Hori T, Oya T, Watanabe K, Kanamori M, Kimura T. Pleomorphic hyalinizing angiectatic tumor arising in the thigh: A case report. Oncol Lett 2014; 7: 1249-1252.

Groisman GM, Bejar J, Amar M, Ben-Izhak O.Pleomorphic hyalinizing angiectatic tumor of soft parts:immunohistochemical study including the expression of vascular endothelial growth factor. Arch Pathol Lab Med 2000; 124:423-6.

Peng HC, Huang MT, Chen DJ, Leung TK, Chu JS. Pleomorphic hyalinizing angiectatic tumor of soft parts. J Formos Med Assoc 2010; 109: 616-20.

Parameshwarappa S, Rodrigues G, Nagpal N,Rao L. Pleomorphic hyalinizing angiectatic tumor of soft parts involving the upper limb.Indian J Surg 2010; 72: 263-4.

Flope AL, Weiss SW. Pleomorphic hyalinizing angiectatic tumor: Analysis of 41 cases supporting evolution from a distinctive precursor lesion. Am J Surg Pathol 2004;28: 1417–25.

Matsumoto K, Yamamoto T. Pleomorphic hyalinizing angiectatic tumor of soft parts: a case report and literature review. Pathol Int 2002;52:664–8.

Silverman JS, Dana MM. Pleomorphic hyalinizing angiectatic tumor of soft parts: immunohistochemical case study shows cellular composition by CD34 + fibroblasts and factor XIIIa + dendrophages. J Cutan Pathol 1997;24:377–83.

F. Tallarigoa, S. Squillacib, I. Putrinoa, N. Zizzic, M. Biscegliad, Pleomorphic hyalinizing angiectatic tumor of the male breast: a heretofore unreported occurrence, Pathol. – Res. Pract. 205 (2009) 69–73.

C.D.M. Fletcher, K.K. Unni, F.E. Mertens, WHO Classification of Tumors of Soft Tissue and Bone, International Agency for Research on Cancer (IARC), Lyon,2002, 191 pp.

P.S. Brazio, A.L. Morrison, M. Oh, N. Goldberg, C.N. Boutros, Baltimore, Large pleomorphic hyalinizing angiectatic tumor of the forearm: a multidisciplinary perspective, Surgery 159 (May (5)) (2016) 1471–1473.

Y. Changchien, P. Bocskai, I. Kovács, Z. Hargitai, S. Kollár, M. Török, Pleomorphic hyalinizing angiectatic tumor of soft parts: case report with unusual ganglion-like cells and review of the literature, Pathol. – Res. Pract. 210 (2014)1146–1151.

D.V. Kazakov, M. Pavlovsky, P. Mukensnabl, M. Michal, Pleomorphic hyalinizing angiectatic tumor with a sarcomatous component recurring as high-grade myxofibrosarcoma, Pathol. Int. 57 (2007) 281–284.

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IssueVol 57, No 3 (2019) QRcode
SectionCase Report(s)
DOI https://doi.org/10.18502/acta.v57i3.1824
Keywords
Pleomorphic hyalinizing angiectatic tumor Pleomorphic hyalinizing angiectatic tumor of the soft parts Subcutaneous Ankle

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How to Cite
1.
Sadeghi A, Mardani A, Mortazi S, Rakhshani N. A Subcutaneous Pleomorphic Hyalinizing Angiectatic Tumor of Soft Parts of the Right Ankle: A Case Report. Acta Med Iran. 2019;57(3):197-199.