siRNA Delivery Technology for Cancer Therapy: Promise and Challenges

  • Fateme Karimi Dermani Department of Molecular Medicine, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
  • Farid Azizi Jalilian Department of Medical Microbiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
  • Hossein Hossienkhani Innovation Center for Advanced Technology, Matrix, Inc., New York, NY 10029, USA.
  • Razieh Ezati Institute of Medical Biotechnology, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran.
  • Razieh Amini Department of Molecular Medicine, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran. AND Molecular Medicine Research Center, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Keywords: Small interfering RNA (siRNA), Cancer therapy, Delivery systems, Nanoparticles

Abstract

Small interfering RNAs (siRNA) technology has shown great promise as a new class of therapeutic interventions for the treatment of cancer and other diseases. It is a remarkable endogenous pathway that can regulate sequence-specific gene silencing. Despite the excitement about possible applications of this biological process for sequence-specific gene regulation, the major limitations against the use of siRNA-based therapeutics are their rapid degradation by serum nuclease, poor cellular uptake, and rapid renal clearance following systemic delivery, off-target effects and the induction of immune responses. Many researchers have tried to overcome these limitations by developing nuclease-resistant chemically-modified siRNAs and a variety of synthetic and natural biodegradable lipids and polymers to enhance the efficacy and safety profiles of siRNA delivery. Ideal siRNA-based delivery systems for cancer therapy must be clinically suitable, safe and effective. In this review, we introduce the greatest challenges in achieving efficient RNAi delivery and discuss design criteria and various delivery strategies for cancer therapy, including chemical modifications, lipid-based nano-vectors, polymer-mediated delivery systems, conjugate delivery systems, and others.

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Published
2019-03-12
How to Cite
1.
Karimi Dermani F, Azizi Jalilian F, Hossienkhani H, Ezati R, Amini R. siRNA Delivery Technology for Cancer Therapy: Promise and Challenges. Acta Med Iran. 57(2):83-93.
Section
Review Article(s)