Ectopic Cushing’s Syndrome as the Initial Presentation of Pulmonary Carcinoid Tumor Managed by Etomidate: A Case Report
-
Masoud Mohebbi
,
Shohreh Vojouhi
,
Seyed Alireza Javadinia
,
Faeze Keihanian
,
Mohammad Ali Yaghoubi
,
Ali Motamedzadeh Torghabeh
Abstract
Ectopic increase of adrenocorticotropic hormone (ACTH) or ectopic Cushing syndrome is a rare initial presentation of small cell carcinoma and carcinoid tumor of the lung. Here, we reported a 36-year-old male with atypical symptoms of Cushing syndrome managed by Etomidate that had a central pulmonary nodule, and pathologic evaluation of pulmonary lobectomy revealed the diagnosis of well-differentiated, low-grade typical carcinoids of lung.
Newell-Price J, Trainer P, Besser M, Grossman A. The Diagnosis and Differential Diagnosis of Cushing’s Syndrome and Pseudo-Cushing’s States. Endocrine Reviews. 1998;19(5):647-72.
Vaduganathan M, Nagarur A, Kerr DA, Lauter KB, Padmanabhan A, Raghavan S, et al. Metastatic pancreatic neuroendocrine tumor with ectopic adrenocorticotropic hormone production. Proceedings (Baylor University Medical Center). 2015;28(1):46.
Meisinger QC, Klein JS, Butnor KJ, Gentchos G, Leavitt BJ. CT features of peripheral pulmonary carcinoid tumors. American Journal of Roentgenology. 2011;197(5):1073-80.
Caplin ME, Baudin E, Ferolla P, Filosso P, Garcia-Yuste M, Lim E, et al. Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids. Annals of oncology. 2015;26(8):1604-20.
Bhansali A, Walia R, Rana S, Dutta P, Radotra B, Khandelwal N, et al. Ectopic Cushing's syndrome: experience from a tertiary care centre. Indian Journal of Medical Research. 2009;129(1):33.
El Hayek MS, Choucair M, Arabi A. Cushing Syndrome due to Ectopic ACTH Secretion Presenting With Lower Limb Edema and Pulmonary Nocardia Infection: Case Report and Review of the Literature. Journal of Endocrinology and Metabolism. 2016;6(5):158-61.
Loriaux DL. Diagnosis and Differential Diagnosis of Cushing’s Syndrome. New England Journal of Medicine. 2017;376(15):1451-9.
Howlett TA, Drury PL, Perry L, Doniach I, Rees LH, Besser GM. Diagnosis and management of ACTH-dependent Cushing's syndrome: comparison of the features in ectopic and pituitary ACTH production. Clinical endocrinology. 1986;24(6):699-713.
Shepherd FA, Laskey J, Evans WK, Goss PE, Johansen E, Khamsi F. Cushing's syndrome associated with ectopic corticotropin production and small-cell lung cancer. Journal of Clinical Oncology. 1992;10(1):21-7.
Mendonca B, Madureira G, Bloise W, Albergaria A, Halpern A, Liberman B, et al. Cushing syndrome due to ectopic ACTH secretion. Revista paulista de medicina. 1989;107(1):29-36.
Pass HI, Doppman JL, Nieman L, Stovroff M, Vetto J, Norton JA, et al. Management of the ectopic ACTH syndrome due to thoracic carcinoids. The Annals of thoracic surgery. 1990;50(1):52-7.
Reza‐Albarrán AA, Andino Ríos GG, Gómez Herrera LG. Etomidate in the control of severe Cushing's syndrome by neuroendocrine carcinoma. Clinical Case Reports. 2018;6(5):851-4.
Johnson TN, Canada TW. Etomidate use for Cushing's syndrome caused by an ectopic adrenocorticotropic hormone-producing tumor. The Annals of pharmacotherapy. 2007;41(2):350-3.
Drake W, Perry L, Hinds C, Lowe D, Reznek R, Besser G. Emergency and prolonged use of intravenous etomidate to control hypercortisolemia in a patient with Cushing’s syndrome and peritonitis. The Journal of Clinical Endocrinology & Metabolism. 1998;83(10):3542-4.
Tong CV, Hussein Z. Ectopic ACTH Syndrome–Experience with Etomidate. Journal of the ASEAN Federation of Endocrine Societies. 2017;32(1):54.
| Files | ||
| Issue | Vol 57, No 7 (2019) | |
| Section | Case Report(s) | |
| DOI | https://doi.org/10.18502/acta.v57i7.2336 | |
| Keywords | ||
| Ectopic cushing Carcinoid tumor Etomidate | ||
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