Original Article

Effect of Gestational Hypertension on Neonatal Hemoglobin Level

Abstract

This study aims to determine the effect of gestational hypertension on neonatal hemoglobin levels. This cohort study was performed on 150 pregnant women, 60 of whom had gestational hypertension and 90 were healthy. Participants were selected using sequential and quota non-probability sampling methods, respectively. The data were collected from interviews and examination forms. The newborns’ umbilical cords were clamped 30-60 sec after the delivery in both groups. Umbilical cord blood samples were taken to determine neonatal hemoglobin levels and sent to the laboratory immediately. Independent t-test was used to compare the two groups in terms of mean hemoglobin; general linear model with an identical link function was used to compare the two groups in terms of mean hemoglobin, considering the effect of confounding variables. SPSS software version 25 was used for the statistical analysis of the data. The statistical significance level in this study was considered to be 0.05. The mean neonatal hemoglobin level in women with gestational hypertension was significantly higher than that in the healthy group (16.73±1.81 gr/dl vs. 15.56±1.79, P<0.001). This difference remained significant after adjusting for demographic and background variables as well as medical records of the participants (P=0.008). The results revealed the hemoglobin level of newborns of mothers who had gestational hypertension, was higher than newborns of healthy mothers. Therefore, performing proper screening tests and knowledge of the hemoglobin level in these infants routinely helps the healthcare staff to prevent, decide and provide more and more useful services.

1. Braunthal S, Brateanu A. Hypertension in pregnancy: Pathophysiology and treatment. SAGE Open Med 2019;7:2050312119843700.
2. Burwick RM, Rincon M, Beeraka SS, Gupta M, Feinberg BB. Evaluation of Hemolysis as a Severe Feature of Preeclampsia. Hypertension 2018;72:460-5.
3. Shah S, Gupta A. Hypertensive disorders of pregnancy. Cardiol Clin 2019;37:345-54.
4. Umesawa M, Kobashi G. Epidemiology of hypertensive disorders in pregnancy: prevalence, risk factors, predictors and prognosis. Hypertens Res 2017;40:213-20.
5. Yu H, He Y, Mao Z, Dong W, Fu X, Lei X. Hypertensive disorders during pregnancy and elevated blood pressure in the offspring: a systematical review and meta-analysis protocol. Medicine (Baltimore) 2019; 98:e15677.
6. Nzelu D, Dumitrascu-Biris D, Kay P, Nicolaides KH, Kametas NA. Severe hypertension, preeclampsia and small for gestational age in women with chronic hypertension diagnosed before and during pregnancy. Pregnancy Hypertens 2018;14:200-4.
7. Rastegari A, Haghdoost AA, Baneshi MR. Factors influencing drug injection history among prisoners: A comparison between classification and regression trees and logistic regression analysis. Addict Health 2013;5:7-15.
8. Miranda ML, Swamy GK, Edwards S, Maxson P, Gelfand A, James S. Disparities in maternal hypertension and pregnancy outcomes: evidence from North Carolina, 1994–2003. Public Health Rep 2010;125:579-87.
9. Yong HE, Melton PE, Johnson MP, Freed KA, Kalionis B, Murthi P, et al. Genome-wide transcriptome directed pathway analysis of maternal pre-eclampsia susceptibility genes. PLoS One 2015;10:e0128230.
10. Martin RJ, Fanaroff AA, Walsh MC. Fanaroff and Martin's neonatal-perinatal medicine e-book: diseases of the fetus and infant: Elsevier Health Sciences; 2014.
11. Rodrigues Â, Barata C, Marques I, Almeida MC. Diagnosis of white coat hypertension and pregnancy outcomes. Pregnancy Hypertens 2018;14:121-4.
12. Wang Y, Hao M, Sampson S, Xia J. Elective delivery versus expectant management for pre-eclampsia: a meta-analysis of RCTs. Arch Gynecol Obstet 2017;295:607-22.
13. Omani-Samani R, Ranjbaran M, Amini P, Esmailzadeh A, Sepidarkish M, Almasi-Hashiani A. Adverse maternal and neonatal outcomes in women with preeclampsia in Iran. J Matern Fetal Neonatal Med 2019;32:212-6.
14. Nisa MU, Anjum S. Elective induction versus expectant management of mild pre-eclampsia at term. J Coll Physicians Surg Pak 2018;28:677-80.
15. Marins LR, Anizelli LB, Romanowski MD, Sarquis AL. How does preeclampsia affect neonates? Highlights in the disease’s immunity. J Matern Fetal Neonatal Med 2019;32:1205-12.
16. Khazardoost S, Maryamnoorzadeh, Abdollahi A, Shafaat M. Comparison of 8-h urine protein and random urinary protein-to-creatinine ratio with 24-h urine protein in pregnancy. J Matern Fetal Neonatal Med 2012;25:138-40.
17. Mouna K, Doddagowda SM, Junjegowda K, Krishnamurthy L. Changes in haematological parameters in newborns born to preeclamptic mothers-a case control study in a rural hospital. J Clin Diagn Res 2017;11:EC26-9.
18. Okoye HC, Nwogoh B, Odetunde OI. Correlation of hematocrit and Apgar scores in newborns of women with hypertensive disorders in pregnancy. J Neonatal Perinatal Med 2017;10:387-92.
19. Al-bahadily Ak, AL-Omrani A, Mohammed M. The Effect of Pregnancy Induced Hypertension on Complete Blood Count of Newborn. Int J Pediatr 2017;5:5667-76.
20. Farooqui S, Salam A, Anwer E, Ojha P, Singh S. Effect of maternal preeclampsia on neonatal red cell parameters. Indian J Clin Anatomy Physiol 2018;5:85-90.
21. Eman N, Manazir AS, Uzma F, Nasreen N. Comparative study of cord blood hematological profile of neonates born to mothers with and without pregnancy-induced hypertension: A prospective case–control study. Indian J Child Health 2017;4:554-60.
22. Okoye HC, Eweputanna LI, Korubo KI, Ejele OA. Effects of maternal hypertension on the neonatal haemogram in southern Nigeria: A case-control study. Malawi Med J 2016;28:174-8.
Files
IssueVol 61 No 11 (2023) QRcode
SectionOriginal Article(s)
DOI https://doi.org/10.18502/acta.v61i11.16077
Keywords
Hypertension Pregnancy-induced Fetal hemoglobin

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
1.
Khosravi P, Pirdadeh Beiranvand S, Ebrahimzadeh F, Tadayon A, Hasani M. Effect of Gestational Hypertension on Neonatal Hemoglobin Level. Acta Med Iran. 2024;61(11):660-666.