Idiopathic Granulomatous Mastitis and Breast Cancer: Three Cases and Review of 16 Previous Cases
Abstract
Idiopathic Granulomatous Mastitis (IGM) is an inflammatory and benign breast disease that can mimic a wide range of breast diseases (from infection to breast cancer (BC)). IGM affects women in the childbearing age and is more prevalent in Asia. According to similarity of IGM and BC presentation and different treatment pathways, it is important to distinguish between these two diseases. We present three cases; the first one is a 42-year-old woman with IGM 2 years after treatment of a stage two breast carcinoma; and the second and third one is a 46-year-old and 41 years old ladies with breast cancer 4 and 13 years after being diagnosed with IGM. Although the occurrence of IGM and cancer in an individual patient is rare, physicians should be aware of this possibility.
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2. Anoush K, Azizi M, Soleimani V, Rezvani A, Azmoudeh Ardalan F, Jahanbin B. Idiopathic Granulomatous Mastitis: Diagnosis and Histopathologic Features. Arch Breast Cancer 2022;9:272-8.
3. Yaprak Bayrak B, Cam I, Eruyar AT, Utkan NZ. Clinicopathological evaluation of idiopathic granulomatous mastitis patients: A retrospective analysis from a tertiary care hospital in Turkey. Ann Diagn Pathol 2021;55:151812.
4. Ozel L, Unal A, Unal E, Kara M, Erdoğdu E, Krand O, et al. Granulomatous mastitis: is it an autoimmune disease? Diagnostic and therapeutic dilemmas. Surg Today 2012;42:729-33.
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6. Salih AM, Pshtiwan LRA, Abdullah AM, Dhahir HM, Ali HO, Muhialdeen AS, et al. Granulomatous mastitis masking ductal carcinoma in situ: A case report with literature review. Biomed Rep 2023;20:17.
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8. Zhu J, Miao X, Li X, Zhang Y, Lou Y, Chen H, et al. Granulomatous lobular mastitis co-existing with ductal carcinoma in situ: Report of three cases and review of the literature. Ann Diagn Pathol 2024:68:152241.
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10. Kessler E, WollochY. Granulomatous mastitis: a lesion clinically simulating carcinoma. Am J Clin Pathol 1972;58:642-6.
11. Alipour S, Tabatabaeian M, Nafissi N, Fattahiand AS, Astaraki S, Zahernia-Shahrbabaki Z, et al. Idiopathic Granulomatous Mastitis and History of Hypothyroidism: Intervening Data of a Prospective Multicenter Trial and Meta-Analysis of the Existing Literature. Arch Breast Cancer 2023;10:38-47.
12. Odd´o D, Domínguez F, G´omez N, Méndez GP, Navarro ME. Granulomatous lobular mastitis associated with ductal carcinoma in situ of the breast. SAGE Open Med Case Rep 2019;7:2050313x19836583.
13. Ozsen M, Tolunay S, Gokgoz M. Case report: ductal carcinoma in situ within a granulomatous mastitis. Eur J Breast Health 2018;14:186-8.
14. Çalıs H, Kilitçi A. Granulomatous mastitis concurrence with breast cancer. Eur J Breast Health 2018;14:58-60.
15. Limaiem F, Khadhar A, Hassan F, Bouraoui S, Lahmar A, Mzabi S. Coexistence of lobular granulomatous mastitis and ductal carcinoma: a fortuitous association? Pathologica 2013;105:357-60.
16. Zangouri V, Niazkar HR, Nasrollahi H, Homapour F, Ranjbar A, Seyyedi MS. Benign or premalignant? Idiopathic granulomatous mastitis later diagnosed as ductal carcinoma breast cancer: Case report and review of literature. Clin Case Rep 2022;10:e06323.
17. Evans J, Sisk L, Chi K, Brown S, To H. Concurrent granulomatous mastitis and invasive ductal cancer in contralateral breasts—a case report and review. J Surg Case Rep 2021;2021:rjab519.
18. Gautier N, Lalonde L, Tran-Thanh D, El Khoury M, David J, Labelle M, et al. Chronic granulomatous mastitis: Imaging, pathology and management. Eur J Radiol 2013;82:e165-75.
19. Wong FY, Tham WY, Nei WL, Lim C, Miao H. Age exerts a continuous effect in the outcomes of Asian breast cancer patients treated with breast- conserving therapy. Cancer Commun (Lond) 2018;38:39.
20. Pourriahi R, Omranipour R, Alipour S, Hajimaghsoudi L, Mashoori N, Yazadnkhah Kenary A, et al. Clinical characteristics of breast cancer patients admitted to academic surgical wards in Tehran, Iran: an analytical cross-sectional study. BMC Women’s Health 2023;23:511.
2. Anoush K, Azizi M, Soleimani V, Rezvani A, Azmoudeh Ardalan F, Jahanbin B. Idiopathic Granulomatous Mastitis: Diagnosis and Histopathologic Features. Arch Breast Cancer 2022;9:272-8.
3. Yaprak Bayrak B, Cam I, Eruyar AT, Utkan NZ. Clinicopathological evaluation of idiopathic granulomatous mastitis patients: A retrospective analysis from a tertiary care hospital in Turkey. Ann Diagn Pathol 2021;55:151812.
4. Ozel L, Unal A, Unal E, Kara M, Erdoğdu E, Krand O, et al. Granulomatous mastitis: is it an autoimmune disease? Diagnostic and therapeutic dilemmas. Surg Today 2012;42:729-33.
5. Kaviani A, Zand S, Karbakhsh M, Azmoudeh Ardalan F. Synchronous Idiopathic Granulomatosis Mastitis and Breast Cancer: A Case Report and Review of Literature. Arch Breast Cancer 2016;4:32-6.
6. Salih AM, Pshtiwan LRA, Abdullah AM, Dhahir HM, Ali HO, Muhialdeen AS, et al. Granulomatous mastitis masking ductal carcinoma in situ: A case report with literature review. Biomed Rep 2023;20:17.
7. Yoshida N, Nakatsubo M, Yoshino R, Ito A, Ujiie N, Yuzawa S, et al. Concurrent Granulomatous Mastitis and Ductal Carcinoma in Situ. Cureus 2023;15:e38377.
8. Zhu J, Miao X, Li X, Zhang Y, Lou Y, Chen H, et al. Granulomatous lobular mastitis co-existing with ductal carcinoma in situ: Report of three cases and review of the literature. Ann Diagn Pathol 2024:68:152241.
9. Mazlan L, SuhaiMi SN, JaSMin SJ, Nani Harlina Md latar, Sellymiah adzMan, Rohaizak MuhaMMad. Breast Carcinoma Occurring from Chronic Granulomatous Mastitis. Malays J Med Sci 2012;19:82-5.
10. Kessler E, WollochY. Granulomatous mastitis: a lesion clinically simulating carcinoma. Am J Clin Pathol 1972;58:642-6.
11. Alipour S, Tabatabaeian M, Nafissi N, Fattahiand AS, Astaraki S, Zahernia-Shahrbabaki Z, et al. Idiopathic Granulomatous Mastitis and History of Hypothyroidism: Intervening Data of a Prospective Multicenter Trial and Meta-Analysis of the Existing Literature. Arch Breast Cancer 2023;10:38-47.
12. Odd´o D, Domínguez F, G´omez N, Méndez GP, Navarro ME. Granulomatous lobular mastitis associated with ductal carcinoma in situ of the breast. SAGE Open Med Case Rep 2019;7:2050313x19836583.
13. Ozsen M, Tolunay S, Gokgoz M. Case report: ductal carcinoma in situ within a granulomatous mastitis. Eur J Breast Health 2018;14:186-8.
14. Çalıs H, Kilitçi A. Granulomatous mastitis concurrence with breast cancer. Eur J Breast Health 2018;14:58-60.
15. Limaiem F, Khadhar A, Hassan F, Bouraoui S, Lahmar A, Mzabi S. Coexistence of lobular granulomatous mastitis and ductal carcinoma: a fortuitous association? Pathologica 2013;105:357-60.
16. Zangouri V, Niazkar HR, Nasrollahi H, Homapour F, Ranjbar A, Seyyedi MS. Benign or premalignant? Idiopathic granulomatous mastitis later diagnosed as ductal carcinoma breast cancer: Case report and review of literature. Clin Case Rep 2022;10:e06323.
17. Evans J, Sisk L, Chi K, Brown S, To H. Concurrent granulomatous mastitis and invasive ductal cancer in contralateral breasts—a case report and review. J Surg Case Rep 2021;2021:rjab519.
18. Gautier N, Lalonde L, Tran-Thanh D, El Khoury M, David J, Labelle M, et al. Chronic granulomatous mastitis: Imaging, pathology and management. Eur J Radiol 2013;82:e165-75.
19. Wong FY, Tham WY, Nei WL, Lim C, Miao H. Age exerts a continuous effect in the outcomes of Asian breast cancer patients treated with breast- conserving therapy. Cancer Commun (Lond) 2018;38:39.
20. Pourriahi R, Omranipour R, Alipour S, Hajimaghsoudi L, Mashoori N, Yazadnkhah Kenary A, et al. Clinical characteristics of breast cancer patients admitted to academic surgical wards in Tehran, Iran: an analytical cross-sectional study. BMC Women’s Health 2023;23:511.
| Files | ||
| Issue | Vol 62 No 6 (2024) | |
| Section | Case Report(s) | |
| Keywords | ||
| Idiopathic granulomatous mastitis (IGM) Granulomatous mastitis Breast cancer Lobular granulomatous mastitis | ||
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Mohammadi Zavieh M, Omranipour R, Alipour S, Sarkardeh M. Idiopathic Granulomatous Mastitis and Breast Cancer: Three Cases and Review of 16 Previous Cases. Acta Med Iran. 2025;62(6):378-380.
