Association of PECAM1 Val125Leu and Gly670Arg Polymorphisms With Risk of Atherosclerosis in a Lur Population of Iran
Abstract
According to importance of PECAM1 in pathogenesis atherosclerosis, we intend to investigate the Val125Leu and Gly670Arg polymorphisms with risk of atherosclerosis in the Lur population of Iran among the individuals who underwent coronary angiography. A genetic association study was performed on 154 approved cases of atherosclerosis and 145 ruled out cases for atherosclerosis based on the expert opinion of interventional cardiologists. Atherogenic indices including atherogenic coefficient (AC), non-HDL-C fraction, Castelli’s Risk Indices-I and -II (CRI-I and -II), atherogenic index of plasma (AIP), and Triglycerides-Glucose (TYG) were all calculated. Logistic regression was used and odds ratio (OR) was reported. Genotype Leu/Leu showed an association with increased risk of atherosclerosis. However, this association was not statistically significant (odds ratio [OR]=1.86, P=0.066). Allele Leu showed an association with increased risk of atherosclerosis. However, this association was not statistically significant (OR=1.34, P=0.069). For polymorphism Gly670Arg, no genotype or allele was associated with risk of atherosclerosis (P>0.05). The most important atherogenic index was AC (area under curve=0.719). After adjusting genotype Leu/Leu with AC as well as age, gender and body mass index, a significant harmful effect was observed for this genotype (OR=2.35, P=0.041). Susceptibility to atherosclerosis does not have a crude association with Val125Leu and Gly670Arg polymorphisms of PECAM1 gene among the patients with acute chest pain in Lur population of Iran. However, besides AC and some demographic variables, genotype Leu/Leu showed a harmful association
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19. Lu S, Guo S, Hu F, Guo Y, Yan L, Ma W, et al. The Associations Between the Polymorphisms of Vitamin D Receptor and Coronary Artery Disease: A Systematic Review and Meta-Analysis. Medicine 2016;95:21:e3467.
20. Zhao QR, Lei YY, Li J, Jiang N, Shi JP. Association between apolipoprotein E polymorphisms and premature coronary artery disease: a meta-analysis. Clin Chem Lab Med 2017;55:2:284-98.
21. Zintzaras E, Raman G, Kitsios G, Lau J. Angiotensin-converting enzyme insertion/deletion gene polymorphic variant as a marker of coronary artery disease: a meta-analysis. Arch Intern Med 2008;168:10:1077-89.
22. Hou H, Wang C, Sun F, Zhao L, Dun A, Sun Z. Association of interleukin-6 gene polymorphism with coronary artery disease: an updated systematic review and cumulative meta-analysis. Inflamm Res 2015;64:9:707-20.
23. Khoshbin M, Ahmadi SAY, Cheraghi M, Nouryazdan N, Birjandi M, Shahsavari G. Association of E-Selectin gene polymorphisms and serum E-Selectin level with risk of coronary artery disease in lur population of Iran. Arch Physiol Biochem 2020:1-6.
24. Akpınar O, Bozkurt A, Acartürk E, Seydaoğlu G. A new index (CHOLINDEX) in detecting coronary artery disease risk. Anadolu Kardiyol Derg 2013;13:4:315-9.
25. Oguejiofor OC, Onwukwe CH, Odenigbo CU. Dyslipidemia in Nigeria: prevalence and pattern. Ann Afr Med 2012;11:4:197-202.
26. Xia T, Liu X, Du CJ, Jin X, Kong XQ, Li G. Association of Leu125Val polymorphisms in the PECAM-1 gene with the risk of coronary heart disease: a meta-analysis. Int J Clin Exp Med 2015;8:2:2219.
27. Sahebkar A, Morris DR, Biros E, Golledge J. Association of single nucleotide polymorphisms in the gene encoding platelet endothelial cell adhesion molecule-1 with the risk of myocardial infarction: a systematic review and meta-analysis. Thromb Res 2013;132:2:227-33.
28. Li Y, Wang S, Zhang D, Xu X, Yu B, Zhang Y. The association of functional polymorphisms in genes expressed in endothelial cells and smooth muscle cells with the myocardial infarction. Hum Genomics 2019;13:1:1-10.
29. Dobiásová M. Atherogenic index of plasma [log(triglycerides/HDL-cholesterol)]: theoretical and practical implications. Clin Chem 2004;50:7:1113-5.
30. Sacks D, Baxter B, Campbell BCV, Carpenter JS, Cognard C, Dippel D, et al. Multisociety Consensus Quality Improvement Revised Consensus Statement for Endovascular Therapy of Acute Ischemic Stroke. Int J Stroke 2018;13:6:612-32.
31. Fu L, Zhou Y, Sun J, Zhu Z, Xing Z, Zhou S, et al. Atherogenic index of plasma is associated with major adverse cardiovascular events in patients with type 2 diabetes mellitus. Cardiovasc Diabetol 2021;20:1:201.
2. Yahagi K, Davis HR, Arbustini E, Virmani R. Sex differences in coronary artery disease: Pathological observations. Atheroscler 2015;239:1:260-7.
3. Nasiri B, Aghdam NK, Separham A, Salmasi R, Daviran N, Parizad R, et al. Investigating the Relationship Between Hardness of Drinking-Water and Severity of Coronary Artery Disease Based on Angiographic Findings in East Azerbaijan Province, Iran. Crescent J Med Biol Sci 2019;6:2:226-30.
4. Sillesen H. Carotid Intima-media Thickness and/or Carotid Plaque: What is Relevant? Eur J Vasc Endovasc Surg 2014;48:2:115-7.
5. Bom MJ, Van Der Heijden DJ, Kedhi E, Van Der Heyden J, Meuwissen M, Knaapen P, et al. Early detection and treatment of the vulnerable coronary plaque: can we prevent acute coronary syndromes? Circ Cardiovasc Imaging 2017;10:5:e005973.
6. Yalameha B. Antioxidant therapy to improve or resolve atherosclerosis; new hopes and current trends. J Nephropharmacol 2019;8:2:e18.
7. Gray SP, Di Marco E, Kennedy K, Chew P, Okabe J, El-Osta A, et al. Reactive oxygen species can provide atheroprotection via NOX4-dependent inhibition of inflammation and vascular remodeling. Arterioscler Thromb Vasc Biol 2016;36:2:295-307.
8. Incalza MA, D’Oria R, Natalicchio A, Perrini S, Laviola L, Giorgino F. Oxidative stress and reactive oxygen species in endothelial dysfunction associated with cardiovascular and metabolic diseases. Vasc Pharmacol 2018;100:1-19.
9. Vigetti D, Genasetti A, Karousou E, Viola M, Moretto P, Clerici M, et al. Proinflammatory cytokines induce hyaluronan synthesis and monocyte adhesion in human endothelial cells through hyaluronan synthase 2 (HAS2) and the nuclear factor-κB (NF-κB) pathway. J Biol Chem 2010;285:32:24639-45.
10. Reiss AB, Glass AD. Atherosclerosis: immune and inflammatory aspects. J Invest Med 2006;54:3:123-31.
11. Demerath E, Towne B, Blangero J, Siervogel R. The relationship of soluble ICAM-1, VCAM-1, P-selectin and E-selectin to cardiovascular disease risk factors in healthy men and women. Ann Hum Biol 2001;28:6:664-78.
12. Galkina E, Ley K. Vascular adhesion molecules in atherosclerosis. Arterioscler Thromb Vasc Biol 2007;27:11:2292-301.
13. Rached FH, Chapman MJ, Kontush A. An overview of the new frontiers in the treatment of atherogenic dyslipidemias. Clin Pharmacol Ther 2014;96:1:57-63.
14. Perk J, De Backer G, Gohlke H, Graham I, Reiner Z, Verschuren M, et al. European Guidelines on cardiovascular disease prevention in clinical practice (version 2012). The Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of nine societies and by invited experts). Eur Heart J 2012;33:13:1635-701.
15. Nwagha UI, Ikekpeazu EJ, Ejezie FE, Neboh EE, Maduka IC. Atherogenic index of plasma as useful predictor of cardiovascular risk among postmenopausal women in Enugu, Nigeria. Afr Health Sci 2010;10:3:248-52.
16. Criqui MH, Golomb BA. Epidemiologic aspects of lipid abnormalities. Am J Med 1998;105:1a:48s-57s.
17. Khan SH, Sobia F, Niazi NK, Manzoor SM, Fazal N, Ahmad F. Metabolic clustering of risk factors: evaluation of Triglyceride-glucose index (TyG index) for evaluation of insulin resistance. Diabetol Metab Syndr 2018;10:1:1-8.
18. Nikpay M, Goel A, Won H-H, Hall LM, Willenborg C, Kanoni S, et al. A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease. Nature Genet 2015;47:10:1121.
19. Lu S, Guo S, Hu F, Guo Y, Yan L, Ma W, et al. The Associations Between the Polymorphisms of Vitamin D Receptor and Coronary Artery Disease: A Systematic Review and Meta-Analysis. Medicine 2016;95:21:e3467.
20. Zhao QR, Lei YY, Li J, Jiang N, Shi JP. Association between apolipoprotein E polymorphisms and premature coronary artery disease: a meta-analysis. Clin Chem Lab Med 2017;55:2:284-98.
21. Zintzaras E, Raman G, Kitsios G, Lau J. Angiotensin-converting enzyme insertion/deletion gene polymorphic variant as a marker of coronary artery disease: a meta-analysis. Arch Intern Med 2008;168:10:1077-89.
22. Hou H, Wang C, Sun F, Zhao L, Dun A, Sun Z. Association of interleukin-6 gene polymorphism with coronary artery disease: an updated systematic review and cumulative meta-analysis. Inflamm Res 2015;64:9:707-20.
23. Khoshbin M, Ahmadi SAY, Cheraghi M, Nouryazdan N, Birjandi M, Shahsavari G. Association of E-Selectin gene polymorphisms and serum E-Selectin level with risk of coronary artery disease in lur population of Iran. Arch Physiol Biochem 2020:1-6.
24. Akpınar O, Bozkurt A, Acartürk E, Seydaoğlu G. A new index (CHOLINDEX) in detecting coronary artery disease risk. Anadolu Kardiyol Derg 2013;13:4:315-9.
25. Oguejiofor OC, Onwukwe CH, Odenigbo CU. Dyslipidemia in Nigeria: prevalence and pattern. Ann Afr Med 2012;11:4:197-202.
26. Xia T, Liu X, Du CJ, Jin X, Kong XQ, Li G. Association of Leu125Val polymorphisms in the PECAM-1 gene with the risk of coronary heart disease: a meta-analysis. Int J Clin Exp Med 2015;8:2:2219.
27. Sahebkar A, Morris DR, Biros E, Golledge J. Association of single nucleotide polymorphisms in the gene encoding platelet endothelial cell adhesion molecule-1 with the risk of myocardial infarction: a systematic review and meta-analysis. Thromb Res 2013;132:2:227-33.
28. Li Y, Wang S, Zhang D, Xu X, Yu B, Zhang Y. The association of functional polymorphisms in genes expressed in endothelial cells and smooth muscle cells with the myocardial infarction. Hum Genomics 2019;13:1:1-10.
29. Dobiásová M. Atherogenic index of plasma [log(triglycerides/HDL-cholesterol)]: theoretical and practical implications. Clin Chem 2004;50:7:1113-5.
30. Sacks D, Baxter B, Campbell BCV, Carpenter JS, Cognard C, Dippel D, et al. Multisociety Consensus Quality Improvement Revised Consensus Statement for Endovascular Therapy of Acute Ischemic Stroke. Int J Stroke 2018;13:6:612-32.
31. Fu L, Zhou Y, Sun J, Zhu Z, Xing Z, Zhou S, et al. Atherogenic index of plasma is associated with major adverse cardiovascular events in patients with type 2 diabetes mellitus. Cardiovasc Diabetol 2021;20:1:201.
| Files | ||
| Issue | Vol 64 No 8 (2026) | |
| Section | Original Articles | |
| Keywords | ||
| Adhesion molecules Genetic association study Genetic epidemiology Medical anthropology Atherogenic indices | ||
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How to Cite
1.
Khoshbin M, Ahmadi SAY, Ahmadpour F, Shahsavari G. Association of PECAM1 Val125Leu and Gly670Arg Polymorphisms With Risk of Atherosclerosis in a Lur Population of Iran. Acta Med Iran. 2026;64(8):499-505.
