LYMPHOCYTE SUBPOPULATIONS AND CELL-MEDIATED IMMUNITY IN MULTIPLE SCLEROSIS IN IRAN

Abstract

Thirty seven randomly selected patients suffering from multiple s c l e r os i s (MS) (17 males and 20 females)and 30 healthy control subjects were studied for the lymphocyte subpopulations and ce l l -Medi a t e d immunity.We obs e r ved a decrease of the total T-cells and an increase of a ctive T-Lymphocytes and B ce l l s , In MS p at i ent s as compared t o normal controls. The inability of MS lymphocytes t o measles antigen by LMT or LTT in our e xpe r i me nt s could be due t o T-lymphocyte dysfunction.