EFFECT OF LEVAMISOLE ON POTENTIATION OF CELL MEDIATED IMMNITY IN RHEUMATOID ARTHRITIS

Abstract

The leukocyte mi gration test (LHT) in the prese nce of na t i v e IgG, and l l e v amis ole were studi ed in 9 patients su f f e ring from cla s s i c a l r h e umatoid ar.thri t i s be f o r e a nd after treatment with l evamisole . Fi f teen heal thy b l o od dono rs we r e s i mi l a r ly l nvestig ated a s cont r o ls .
T- l ympho c yte s ub-popu lations (To ta l a nd active) a nd B-c el l s were als o measured i n both g r o ups simult ane ous l y by E a nd EAC- rosette fo rma t ion Th e results show a significantly diminished leukocyte i nh i b i t o r y fac tor (LIP) i n t he p r e sence of nativ a IgG after trea tment wi t h l e v ami s o l e a nd a signifi c a nt inc r e a s e o f active T- c ells in th i s g roup o f patie n t s. In add i t i o n a f t e r treatment tIle Inigration i nde x
show an increase i n t he presence o f l e v ami s o l e. We have a lso o b s e r v e d a good cor r e l a t ion between the clinical response o f l e vami sole and ou r immunological d a t a.