IMBALANCE OF T-CELL SUBSETS IN IRANIAN ALLERGIC RHINITIS PATIENTS

Abstract

r'Iwenty-nine patients were studied to determine the number of CJ).j+ Tscell subsets in Iranian allergic rhinitis patients. The result was compared with that a/twenty-four nonatopic controls. The number of11 and CDS+T cell')and levels ofspeafic IgE and /g(;4 against weed pollens were also studied The number of lymphocyte subset, tltat is, CD-/+ C/)29+and C1Jf CJ)451t cells were determined hy doublelabeling immunofluorescence assay. The results showed that the number ofClJ-I+ CD.f.5It cells to; significantly higher in the patients (626 ± 251.-1cell')per one micro/iter ofperipheral blood) than in control subjects (479A ± 78.2 cell per one microliter) (P <().05). However, there WlLf no statistical difference between the number oJCJ).f+ CD29+cells in the tH'O groups. There were no correlation between the number of CD.f CD.f5It cells ill tlte peripheral blood of allergic patients and levels of total and specific IgE, hut a direct correlation was found between tlte levels ofspecific IgE and specific IgG.j ill the sera oj allergic patients (r=O.55, P < 0.0(2).