CORRELATION OF BLOOD LEVELS OF CYCLOSPORINE AND IT'S METABOLITES AND LOCAL FACTORS WITH GINGIVAL OVERGROWTH IN IRANIAN RENAL ALLOGRAFT PATIENTS

Abstract

Forty renal allograft patients with three months under immunosuppression by cycloserine were examined for their gingival overgrowth and it's correlation with several parameters including the trough levels of blood cyclosporine and it's metabolites measured by the fluorescence polarization immunoassay technique. No correlation was found between the scores of gingival overgrowth and both the age of patients and duration of cyclosporine therapy. Also, there was no correlation between the scores of gingival overgrowth and the levels of dental plaque. Our findings confirm the effective role of gingival inflammation as a local predisposing factor and also suggest the potential toxic action of cyclosporine metabolites on development of gingival overgrowth or it's accentuation.