EFFECTS OF ORAL CONTRACEPTIVES ON COAGULATING FACTORS

Abstract

Thirty young, healthy, nonsmoking women (mean age approximately 28 years) taking low-dose oral contraceptive pills were recruited for the study of the effects of these pills on coagulating factors. Twenty subjects were taking LD pill (Ethinyl estradiol 0.03 mg, levonorgestrel 0.15 mg) and 10 others were taking Cilest (Ethinyl estradiol 0.035 mg, Norgestimate 0.25 mg) for six months. The control subjects did not receive any oral contraceptives or other medications. Our results showed that:
1. There is no significant difference between the effects of LD and Cilest (with a different progestin content) on coagulating factors.
2. No significant changes were observed between both LD users and controls in PT, APTT, and fibrinogen levels.
3. No significant changes were observed between both Cilest users and controls in PT, APTT, and fibrinogen levels.