CYTOKINE PATTERN OF TH1 AND TH2 CELLS IN PREGNANCY

Abstract

Experimental and clinical investigations indicate that antibody production and Tvliclper 2 (TN2) cvtokinc pattern, cg; Irucrtcukinc - -I, 10 (JL.J, ILID) arc domin ant during pregnancy_ COflSCqllCIlI~"" The T-/iclpa 1 (THI) celts activities decrease in pregnancy. Thus the cell- mediated immunity is paniattv depressed. All these events help fetus as an allograft survives ill the mother's wems. III this research we: measured Tli cvtokincs in the sera of hcalthv prcgncl!lf and llOfl-preglJ{mr women (IL]. IL-I. intcrfron-gannna; IFN-y). Pregnant women '""1101"'(~d s(l,'lliftcaw decrease ill mean semm level of IL2 and IFN - Y. this means depression of cell- mediated immunity. This /illdillt; explains increased incidence oj some of the intmccllutvr injections ami survival 0/ the [ctus during pregnancy.