RESULTS OF ALLOGENIC BONE MARROW TRANSPLANTATION IN CML IN IRAN

Abstract

Nineteen patterns with CML have been transplanted in our Bone Marrow Transplantation (BMT) section since 1991, The mean age of these patients was 26.05 (SD = 9.35). Our conditioning regimen for these patients was cyclophosphamide 60mglkg for 2 days and busulfan 4mglkg for 4 consecutive days. Eleven patients are still alive arid eight patients died during follow-up ranging from 6 months to 5 years. This review revealed a poor outcome for patients older than 30. There was also a rise in the mortality rate when the interval between diagnosis and BMT was longer than 2 years. In contrast with some previous reports, we found no relationship between spleen size in the pre-transplant period and BMT outcome, however recurrence of CM L after BMT correlates strongly with spleen size (P<0.t)01). Cellular recovery (WBC > 1000/ml, PMN > 5001ml. PLT > 1000001ml) correlates directly with spleen size as well (P<0,05).