THE EFFECTS OF PGE1 AND INDOMETHACIN ON ORTHODONTIC TOOTH MOVEMENT IN RAT

Abstract

 Prostaglandin £j (PGE-^) and indomethacin, a nonstroidal antiinflammatory drug, were separately administered during ortliodontic tooth movement in rats. At the beginning, an orthodontic appliance was placed and activated in male albinos rats. In tlie first examination, the experimental group received submucosal injections of PGE-y (10 mg/kg/day) near the first maxillary riglit molars, and alcohol was injected to control group animals as a vehicle similarly. Jn the second examination, indomethacin (10 mg/kg/day) and metiiyl cellulose subcutaneousfy injected to experimental and control groups respectively. Tooth movement was measured at 1,3,5,7,9 and 11 days. In PGE^ group, tooth movement increased significantly at the beginning of seven days as compared to the vehicle injected group and the number of osteoclast and Howship's lacunae were markedly increased. A significant iniiibition of tooth movement occurred beginning at seven days in the indomethacin group compared to the control group.