Contralateral effect of adjuvant induced monoarthritis

Abstract

Experiments wee performed to evaluate the contralateral effect of adjuvant induced mono arthritis. In these experiments Laser Doppler imaging (LDI) was used to investigate changes in blood flow. Adjuvant was applied to induce chronic inflammation. Temperature and knee diameter increased in the first week after administration in the administrated knee joint.Substance p (SP) (a neruokinin with a vaosodjlatory effect) was applied topically to the adjuvant treated knee joint and adjuvant altered and attenuated the effect of SP on blood flow, which was consistent during the three weeks. In the other knee joint (contralateral) inflammatory effect of the adjuvant was revealed during these experiments. An increase in the temperature and knee diameter and alteration of the effect of SP on blood flow was observed in the contralateral knee joint during week one after administration. The increased diameter and temperature abated in week two and three. As the diameter and temperature of ankle joints did not change during the experiments in both ankle it suggests a neurogenic contralateral effect of arthritis