Antineutrophil cytoplasmic autoantibodies in ulcerative colitis

Abstract

Antineutrophil cytoplasmic autoanibodies (ANCA) were detecte in patients with certain autoimmune vascular disease such as Wegner’s granulomatosis, polyarthrits nodosa and systemic luuc erythematous. Indirect immunofluorescence (IIF) technique was employed to detec these autoantibodies.ANCA have been recently detected in some forms of inflammatory bowel disease (IBD), ulcerative colitis (U.C). Crohn’s disease (C.D) and primary sclerosing cholangitis (PSC). By IIF method, two general patterns of ANCA were seen: a cytoplasmic (C-ANCA) and perinuclear form (P-ANCA). In this study we evaluated the presece of ANCA in 52 U.C. patients and 69 matched normal control group by IIF technique, and it’s relationship with disease activity. Site of colon involvement and, lesion extent. The results showed that all control group were ANCA negative, but 58% of patients had ANCA, and most cases (70%) had C- ANCA. The obtained results also revealed that there was no relationship between ANCA and disease activity