"THE EFFECTS OF LOW-DOSE ASPIRIN TREATMENT IN OVARIAN AND UTERINE RESPONSIVENESS, IMPLANTATION AND PREGNANCY RATES IN PATIENTS UNDERGOING ICSI"

Abstract

Vascularization of the follicle may play a role in its maturation and aspirin seems to increase this vascularization.In this investigation we have studied the effects of low-dose aspirin on ovarian and uterine response, implantation and pregnancy rates in patients undergoing intracytoplasmic sperm injection (ICSI). This prospective semirandomized, double-blind, placebo-controlled study was undertaken in Mirza Kochek Khan IVF center. Forty four infertile patients who were undergoing ICSI cycle were studied and they were divided in two groups. The mean age of patients and distribution of the cause of infertility in two groups were similar. In the treatment group, 22 patients underwent controlled ovarian hyperstimulation and received a daily dose of 100 mg aspirin. In the control group 22 patients underwent controlled ovarian hyperstimulation in association with placebo. Number of follicles ≥ 15mm in diameter, number of oocytes retrieved, endometrial thickness, cancellation rate, number of transferred embryos and implantation and pregnancy rates were analyzed in two groups.There was no statistically significant difference between the treatment and control groups for each of the above variables (P >0.05). This study showed that low dose aspirin therapy has no added effect to ovarian and uterine response, implantation and pregnancy rates in ICSI patients.Further studies are recommended for confirmation of our results.