ANTI DEOXYRIBONUCLEIC ACID AND ANTINUCLEAR ANTIGEN ANTIBODIES IN GRAVES’ DISEASE

Abstract

Graves’ disease is an autoimmune disorder characterized by presence of antibodies directed against thyroid stimulating hormone (TSH) receptor or nearby region. Other serological abnormalities like antibodies to double stranded DNA (ds–DNA) and antinuclear antibodies (ANA) have also been observed. We studied antibodies to ds-DNA and ANA in our patients with Graves’ disease and compared them with control group. Sera of 84 patients (29 males, 55 females) with diagnosis of Graves’ disease were prepared and level of antibodies to ds-DNA and ANA were measured and compared with 41 healthy persons (15 males, 26 females). The level of antibodies to ds-DNA and ANA in patients and control group did not show any significant difference. Our results were different from other studies in other countries. The difference may be explained by difference in our method of antibody measurement or genetic background which needs to be confirmed by HLA studies of our population.