A COMPARISON OF DEXAMETASONE AND METOCLOPRAMIDE FOR PREVENTING PAIN ON INJECTION OF DIAZEPAM

Abstract

Intravenous administration of dexamethasone before diazepam injection seems "0 reduce the incidence or pain on injection. We conducted a randomized. prospective, double-blind. placebocontrolled clinical trial to compare effect or dexamethasone, mctoclopramidc ami placebo in reducing the injection pain.:" total of 120 ASA class I and ll mcn aged 20-45 years that needed more than one intravenous access were enrolled in the study and were randomly allocated to one of the three groups: group 1, :2 ml intravenous normal saline and 2 1111 dexamethasone (X mgj: group 2. 2 1111 intravenous normal saline and 2 1111 mctoclopramidc l10 mg), and group 3.:2 ml intravenous dexamethasone (X mg) and 2 ml ructoclopramidc (10 mg). After 30 seconds. I ml diazepam (5 mg) was injected simultaneously into each of patients' hand veins and a maximal visual analog scale (VAS) for pain of each venous discomfort was assessed separately. In group I. the mean of VAS for pain was significantly less in dexamethasone pretreatment than saline pretreatment. In group 2. the mean of VAS for pain was significantly less in mctoclopramidc pretreatment than saline pretreatment. In group 3, the mean of VAS for pain was significantly less in dexamethasone pretreatment than mctocloprauudc pretreatment. There were no significant differences in incidence of pain between pretreatment and placebo in three groups. Dexamethasone or mctoclopramidc pretreatments arc effective in reducing the severity of pain on injection of diazepam and dexamethasone pretreatment has greater efficacy in reducing the intensity of pain.