Original Article

Quality of life of Epileptic Patients Compared to General

Abstract

Epilepsy is a chronic disease that affects different aspects of life; so we studied the quality of life of epileptic patients and compared it with general population of Tehran. We collected clinical and demographic data and studied quality of life by using the Iranian translation of Short Form 36 questionnaire version 2 (SF-36). The questionnaires were filled out by 200 patients with epilepsy referred to the Epilepsy Institute as outpatients. The mean age of our patients was 32.6 years. 54.5% were male. More than 60% of our patients had generalized tonic colonic seizures and seizure frequency was more than once a month in about 40% of them. Patients had lower scores in all subscales of SF-36, which were significantly lower than the general population. Mental health and vitality were the most affected by the disease and physical functioning was the least. Age, marital status, number of children, type of seizure and duration of disease had no effect on quality of life, but gender, educational level, occupation and income did influence quality of life. Clinical factors with significant effects on quality of life were as follows: number of taken drugs, number of adverse effects of drugs, frequency of seizures, and the time passed from last seizure. So we recommend treating patients using least number of drugs with minimum side effects. Striving for seizure free patients is very important and it is vital that we regard quality of life as an important factor in selecting appropriate treatment for patients.

Cecil RL, Bennett JC, Goldman L, editors. Cecil's Textbook of Medicine. 21st ed. Philadelphia, PA: W.B. Saunders; 2000.

Meinardi H, Scott RA, Reis R, Sander JW; ILAE Commission on the Developing World. The treatment gap in epilepsy: the current situation and ways forward. Epilepsia 2001; 42(1): 136-49.

Machin D, Fayers PM. Quality of Life: Assessment, Analysis and Interpretation of Patient Reported Outcomes. 2nd ed.New York: John Wiley & Sons; 2007.

Doughty J, Baker GA, Jacoby A, Lavaud V. Cross-culturaldifferences in levels of knowledge about epilepsy. Epilepsia 2003; 44(1): 115-23.

Jacoby A. Stigma, epilepsy, and quality of life. Epilepsy Behav 2002; 3(6S2): 10-20.

Leidy NK, Elixhauser A, Vickrey B, Means E, Willian MK. Seizure frequency and the health-related quality of life of adults with epilepsy. Neurology 1999; 53(1): 162-6.

Stavem K, Loge JH, Kaasa S. Health status of people with epilepsy compared with a general reference population. Epilepsia 2000; 41(1): 85-90.

el-Hilu SM. Social aspects of epilepsy in Kuwait. Int J Soc Psychiatry 1990; 36(1): 68-73.

Alwash RH, Hussein MJ, Matloub FF. Symptoms of anxiety and depression among adolescents with seizures in Irbid, Northern Jordan. Seizure 2000; 9(6): 412-6.

Baker GA, Jacoby A, Gorry J, Doughty J, Ellina V; SIGN Group. Quality of life of people with epilepsy in Iran, the Gulf, and Near East. Epilepsia 2005; 46(1): 132-40.

Leone MA, Beghi E, Righini C, Apolone G, Mosconi P. Epilepsy and quality of life in adults: a review of instruments. Epilepsy Res 2005; 66(1-3): 23-44.

Jacoby A, Baker GA, Steen N, Buck D. The SF-36 as a health status measure for epilepsy: a psychometric assessment. Qual Life Res 1999; 8(4): 351-64.

Montazeri A, Goshtasebi A, Vahdaninia M, Gandek B. The Short Form Health Survey (SF-36): translation and validation study of the Iranian version. Qual Life Res 2005; 14(3): 875-82.

Mrabet H, Mrabet A, Zouari B, Ghachem R. Health-related quality of life of people with epilepsy compared with a general reference population: a Tunisian study. Epilepsia 2004; 45(7): 838-43.

de Weerd A, de Haas S, Otte A, Trenité DK, van Erp G, Cohen A, et al. Subjective sleep disturbance in patients with partial epilepsy: a questionnaire-based study on prevalence and impact on quality of life. Epilepsia 2004; 45(11): 1397-404.

Argyriou AA, Papapetropoulos S, Polychronopoulos P, Corcondilas M, Argyriou K, Heras P. Psychosocial effects and evaluation of the health-related quality of life in patients suffering from well-controlled epilepsy. J Neurol 2004; 251(3): 310-3.

Hermann BP, Vickrey B, Hays RD, Cramer J, Devinsky O, Meador K, et al. A comparison of health-related quality of life in patients with epilepsy, diabetes and multiple sclerosis.Epilepsy Res 1996; 25(2): 113-8.

Pugh MJ, Copeland LA, Zeber JE, Cramer JA, AmuanME, Cavazos JE, et al. The impact of epilepsy on health status among younger and older adults. Epilepsia 2005; 46(11): 1820-7.

Buck D, Jacoby A, Baker GA, Ley H, Steen N. Crossculturaldifferences in health-related quality of life of people with epilepsy: findings from a European study. Qual Life Res 1999; 8(8): 675-85.

Baker GA, Jacoby A, Buck D, Stalgis C, Monnet D. Quality of life of people with epilepsy: a European study. Epilepsia 1997; 38(3): 353-62.

Birbeck GL, Hays RD, Cui X, Vickrey BG. Seizure reduction and quality of life improvements in people with epilepsy. Epilepsia 2002; 43(5): 535-8.

Malmgren K, Sullivan M, Ekstedt G, Kullberg G, Kumlien E. Health-related quality of life after epilepsy surgery: a Swedish multicenter study. Epilepsia 1997; 38(7): 830-8.

Wagner AK, Bungay KM, Kosinski M, Bromfield EB, Ehrenberg BL. The health status of adults with epilepsy compared with that of people without chronic conditions. Pharmacotherapy 1996; 16(1): 1-9.

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IssueVol 47, No 1 (2009) QRcode
SectionOriginal Article(s)
Keywords
Quality of life SF-36 epilepsy

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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
1.
Rajabi F, Dabiran S, Hatmi ZN, Zamani GR. Quality of life of Epileptic Patients Compared to General. Acta Med Iran. 1;47(1):75-78.