Articles

Prevalence of Congenital Malformations

Abstract

Congenital malformation (CM) will begin to emerge as one of the major childhood health problems .Treatment and rehabilitation of children with congenital malformations are costly and complete recovery is usually impossible. The aim of this study was to determine frequency of CM in Yazd central city of the Islamic Republic of Iran to find out if there has been any difference in the rate and types of CM in this area. This descriptive-observational study carried on 4800 births delivered at all maternity hospitals in Yazd from October 2003 to June 2004. Prevalence of CM was 2.83% (2.86 % in male and 2.68 % in female) out of the 136 cases 69(51.88%) were males and 64 (48.12%) were females and 3 with ambiguous genitalia. Positive family history of CM in sibling was in only 6 cases (4.41%).Overall, musculoskeletal (0.83%), central nerv-ous system (0.47%) and genital system (0.37%) were accounted as the most common. Frequency of CM was more seen in still birth (12.5%) as in comparison to live birth (2.71%). There was not statistical difference be-tween prevalence of CM and neonatal's gender, gestational age, birth order and mother's age, drug ingestion, illness and parental consanguinity. In this study the overall prevalence of congenital malformation among the newborn was higher than those previous reported in Iran and determining the causes of this difference needs more extensive studies.

Hudgins L, Cassidy SB. Congenital anomalies. In: Martin RJ, Fanaroff AA, Walsh MC. Fanaroff and Martin's Neonatal-Perinatal Medicine: Diseases of the Fetus and Infant. 8th ed. Philadelphia: Elisvier; 2006. p. 561-81.

Harris JA, James L. State-by-state cost of birth defects: 1992. Teratology 1997; 56(1-2): 11-6.

Botto LD, Lynberg MC, Erickson JD. Congenital heart defects, maternal febrile illness, and multivitamin use: a population- based study. Epidemiology 2001; 12(5): 485-90.

Al Hosani H, Salah M, Abu-Zeid H, Farag HM, Saade D. The National Congenital Anomalies Register in the United Arab Emirates. East Mediterr Health J 2005; 11(4): 690-9.

Sawardekar KP. Profile of major congenital malformations at Nizwa Hospital, Oman: 10-year review. J Paediatr Child Health 2005; 41(7): 323-30.

Farhud DD, Walizadeh GR, Kamali MS. Congenital malformations and genetic diseases in Iranian infants. Hum Genet 1986; 74(4): 382-5.

Tootoonchi P. Easily identification congenital anomalies. prevalence and risk factors. Acta Medica Iranica 2003; 41(1): 15-19.

Shamohamdi F, Ahadi MA. The survey of congenital malformations in live births in Taleghani hospital. J Arak Uni Med Sci 1997; 1(4): 23-9. [Persian]

Golalipour MJ, Ahmadpour-Kacho M, Vakili MA. Congenital malformations at a referral hospital in Gorgan, Islamic Republic of Iran. East Mediterr Health J 2005; 11(4): 707-15.

Al Arrayed SS. Epidemiology of congenital abnormalities in Bahrain. East Mediterr Health J 1995; 1(2): 248-52.

Verma M, Chhatwal J, Singh D. Congenital malformations: a retrospective study of 10,000 cases. Indian J Pediatr 1991; 58(2): 245-52.

Dutta V, Chaturvedi P. Congenital malformations in rural Maharashtra. Indian Pediatr 2000; 37(9): 998-1001.

Bittar Z. Major congenital malformations presenting in the first 24 hours of life in 3865 consecutive births in south of Beirut. Incidence and pattern. J Med Liban 1998; 46(5): 256-60.

Sawardekar KP. Prevalence of isolated minor congenital anomalies in a regional hospital in Oman. Saudi Med J 2005; 26(10): 1567-72.

Singh R, al-Sudani O. Major congenital anomalies at birth in Benghazi, Libyan Arab Jamahiriya, 1995. East Mediterr Health J 2000; 6(1): 65-75.

Krogsgaard MR, Jensen PK, Kjaer I, Husted H, Lorentzen J, Hvass-Christensen B, et al. Increasing incidence of club foot with higher population density: incidence and geographical variation in Denmark over a 16-year period: an epidemiological study of 936,525 births. Acta Orthop 2006; 77(6): 839-46.

Wallander H, Hovelius L, Michaelsson K. Incidence of congenital clubfoot in Sweden. Acta Orthop 2006; 77(6): 847-52.

Rajabian MH, Aghaei S. Cleft lip and palate in southwestern Iran: an epidemiologic study of live births. Ann Saudi Med 2005; 25(5): 385-8.

Cooper ME, Ratay JS, Marazita ML. Asian oral-facial cleft birth prevalence. Cleft Palate Craniofac J 2006; 43(5): 580-9.

Elahi MM, Jackson IT, Elahi O, Khan AH, Mubarak F, Tariq GB, et al. Epidemiology of cleft lip and cleft palate in Pakistan. Plast Reconstr Surg 2004; 113(6): 1548-55.

DeRoo LA, Gaudino JA, Edmonds LD. Orofacial cleft malformations: associations with maternal and infant characteristics in Washington State. Birth Defects Res A Clin Mol Teratol 2003; 67(9): 637-42.

Vallino-Napoli LD, Riley MM, Halliday J. An epidemiologic study of isolated cleft lip, palate, or both in Victoria, Australia from 1983 to 2000. Cleft Palate Craniofac J 2004; 41(2): 185-94.

Al Omari F, Al-Omari IK. Cleft lip and palate in Jordan: birth prevalence rate. Cleft Palate Craniofac J 2004; 41(6): 609-12.

Chong JH, Wee CK, Ho SK, Chan DK. Factors associated with hypospadias in Asian newborn babies. J Perinat Med 2006; 34(6): 497-500.

Garne E, Rasmussen L, Husby S. Gastrointestinal malformations in Funen county, Denmark: epidemiology, associated malformations, surgery and mortality. Eur J Pediatr Surg 2002; 12(2): 101-6.

O'Nualláin S, Flanagan O, Raffat I, Avalos G, Dineen B. The prevalence of Down syndrome in County Galway. Ir Med J 2007; 100(1): 329-31.

Files
IssueVol 47, No 2 (2009) QRcode
SectionArticles
Keywords
Congenital malformation stillbirth musculoskelet anomaly CNS anomaly cleft lip and palate

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
1.
Akhavan Karbasi S, Golestan M, Fallah R, Mirnaseri F, Barkhordari K, Sadr Bafghee M. Prevalence of Congenital Malformations. Acta Med Iran. 1;47(2):149-153.