Specific Anti Mumps Antibodies (IgG & IgM) in Cerebrospinal Fluid of Mumps Meningoencephalitic Children
-
Samileh Noorbakhsh
,
Naser Javahertrash
,
Hassan Tonekaboni
,
Azardokht Tabatabaei
,
Mohammad Ali Fatoorechi
Abstract
Mumps infection is endemic in Iran. Our objective was to evaluate the presence of anti mumps antibodies ( IgM & IgG) in cerebrospinal fluid in mumps meningoencephalitic children. A prospective/cross-sectional study was performed in Tehran, Iran (2003 to 2004) and serum anti mumps antibodies (IgM) were detected (quantitive; ELISA) in meningoencephaltis patients. Specific anti mumps antibodies (IgM & IgG) were detected in cerebrospinal fluids of mumps meningoencephalitis cases. 43 meningoencephalitic patients were tested (59.2% male and 40.8% female). The age of patients was 79.96 ± 4.7 month. 23 (78.7%) cases had specific mumps IgM in serum. None of cases had IgM antibodies in CSF. Anti mumps IgG antibody was detected in CSF of 7.5% (2/23) cases. We detected lower than expected frequency of local immunity to mumps virus in CSF of our cases. For better serologic diagnosis we recommend more sensitive methods like virus detection (PCR) or short-term culture of lymphocytes from cerebrospinal fluid in future studies.
Trottier H, Philippe P. Scaling properties of childhood infectious diseases epidemics before and after mass vaccination in Canada. J Theor Biol 2005; 235(3): 326-37.
Honda H, Shimizu Y, Rutter M. No effect of MMR withdrawal on the incidence of autism: a total population study. J Child Psychol Psychiatry 2005; 46(6): 572-9.
Fukuda S, Chida E, Kuroda T, Kashiwamura M, Inuyama Y. An anti-mumps IgM antibody level in the serum of idiopathic sudden sensorineural hearing loss. Auris Nasus Larynx 2001; 28 Suppl: S3-5.
Okafuji T, Yoshida N, Fujino M, Motegi Y, Ihara T, Ota Y, et al. Rapid diagnostic method for detection of mumps virus genome by loop-mediated isothermal amplification. J Clin Microbiol 2005; 43(4): 1625-31.
Vojgani M, Hajati J, Bahrami F. Seroepidemiological study of mumps in 74 children 5-10 years old by complement fixation. Iran J Allergy Asthma 2000; 11(1); 33-55.
Moddares S. Etiology of aspetic meningitis. Iranian J Med Sci 1987; 22(3-4): 156-60.
Noorbakhsh S, Rimaz Sh, Aghahosseini F. Study of clinicalcourse and complication of mumps meningoencephalitis. J Iran Uni Med Sci 2002; 48(12): 642-9.
Noorbakhsh S, Ashtiani F, Rimaz Sh, Bakhshayesh M. Mumps meningoencephalitis in pediatric ward of Rasool Akram Hospital in Tehran, Iran, 1999-2000. Med J IslamicRepub of Iran 2004; 18(2): 123-26.
Noorbakhsh S, Farhadi M, Tabatabaei A. Comparative study of mumps serology in SNHL children and unaffected ones. J Iran Uni Med Sci 2006; 48(12); 156-64.
Noorbakhsh S, Siadati A, Farhadi M. Sensory hearing loss in children with Mumps infection. Iranian J Child Hood Neurology 2006; 2: 125-8.
Kacprzak-Bergman I, Zaleska I, Jasonek J. Specific humoral immunity in mumps meningitis in children. Med Sci Monit 2001; 7(5): 977-81.
Glikmann G,Pedersen M,Mordhorst CH. Detection of specific immunoglobulin M to mumps virus in serum and cerebrospinalfluid samples from patients with acute mumpsinfection, using an antibody-capture enzyme immunoassay. Acta Pathol Microbiol Immunol Scand C 1986; 94(4): 145-56.
Forsberg P, Kam-Hansen S, Frydén A. Production of specific antibodies by cerebrospinal fluid lymphocytes in patients with herpes zoster, mumps meningitis and herpes simplex virus encephalitis. Scand J Immunol 1986; 24(3): 261-71.
| Files | ||
| Issue | Vol 47, No 3 (2009) | |
| Section | Original Article(s) | |
| Keywords | ||
| Mumps meningoencephalitis cerebrospinal fluid | ||
| Rights and permissions | |
|
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
