Prevalence of Vitamin D Deficiency among Female Students in Secondary Guidance School in Yazd City
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Abstract
Vitamin D is essential for growth and vitamin D deficiency is important issue in adolescent girls as they have a limited rapid growth period .This cross sectional study was done on 167 female students in secondary guidance school in 2006. Growth Parameters, taking supplementary vitamin D, using sunscreen creams and the type of housing and their avoidance from exposure to sunlight was recorded. Symptoms such as weakness, muscle pain, cramp and early fatigability were asked. 25-Hydroxyvitamin D was measured by RIA method, level less than 20ng /ml was considered as deficiency and less than 8ng/ml as sever deficiency. Study showed only 67 girl(40%) have normal vitamin D level,60% suffered vitamin D deficiency (95% CI 52.3-67.5) and 21% out of them suffered sever deficiency (95% CI 14.8- 27.2).No correlation existed between vitamin D level and BMI in our students.There was a correlation between taking supplementary vitamin D and the serum level of 25-Hydroxyvitamin D (P 0.05) Present study showed that despite the fact that Yazd is a sunny city most of the days even in winter; prevalence of vitamin D deficiency among growing female is concerning and requires preventive interference.
Holick MF. Vitamin D: The underappreciated D-lightful hormone that is important for skeletal and cellular health. Curr Opin Endocrinol Diabetes Obes 2002; 9(1): 87-98.
Raiten DJ, Picciano MF. Vitamin D and health in the 21st century: bone and beyond. Executive summary. Am J Clin Nutr 2004; 80(6 Suppl): 1673S-7S.
Holick MF. Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr 2004; 80(6 Suppl): 1678S-88S.
Glerup H, Mikkelsen K, Poulsen L, Hass E, Overbeck S, Thomsen J, et al. Commonly recommended daily intake of vitamin D is not sufficient if sunlight exposure is limited. J Intern Med 2000; 247(2): 260-8.
Holick MF. Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis. Am J Clin Nutr 2004; 79(3): 362-71.
Mora S, Gilsanz V. Establishment of peak bone mass. Endocrinol Metab Clin North Am 2003; 32(1): 39-63.
El-Hajj Fuleihan G, Nabulsi M, Choucair M, Salamoun M, Hajj Shahine C, Kizirian A, et al. Hypovitaminosis D in healthy schoolchildren. Pediatrics 2001; 107(4): E53.
Sullivan SS, Rosen CJ, Halteman WA, Chen TC, Holick MF. Adolescent girls in Maine are at risk for vitamin D insufficiency. J Am Diet Assoc 2005; 105(6): 971-4.
Rucker D, Allan JA, Fick GH, Hanley DA. Vitamin D insufficiency in a population of healthy western Canadians. CMAJ 2002; 166(12): 1517-24.
Holick MF. Resurrection of vitamin D deficiency and rickets. J Clin Invest 2006; 116(8): 2062-72.
Bishop N. Rickets today: children still need milk and sunshine. N Engl J Med 1999; 341(8): 602-4.
DeLuca HF. Overview of general physiologic features and functions of vitamin D. Am J Clin Nutr 2004; 80(6 Suppl): 1689S-96S.
Bouillon R. Vitamin D: from photosynthesis, metabolism, and action to clinical applications. In: DeGroot LJ, Jameson JL, editors. Endocrinology. 4th ed. Philadelphia: WB Saunders; 2001. p. 1009-28.
Holick MF. Vitamin D: A millenium perspective. J Cell Biochem 2003; 88(2): 296-307.
Stumpf WE, Sar M, Reid FA, Tanaka Y, DeLuca HF. Target cells for 1,25-dihydroxyvitamin D3 in intestinal tract, stomach, kidney, skin, pituitary, and parathyroid. Science.1979; 206(4423): 1188-90.
Hayes CE, Nashold FE, Spach KM, Pedersen LB. The immunological functions of the vitamin D endocrine system. Cell Mol Biol (Noisy-le-grand) 2003; 49(2): 277-300.
Griffin MD, Xing N, Kumar R. Vitamin D and its analogs as regulators of immune activation and antigen presentation. Annu Rev Nutr 2003; 23: 117-45.
Li YC, Kong J, Wei M, Chen ZF, Liu SQ, Cao LP. 1,25- Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system. J Clin Invest 2002; 110(2):229-38.
Dawodu A, Agarwal M, Hossain M, Kochiyil J, Zayed R.Hypovitaminosis D and vitamin D deficiency in exclusively breast-feeding infants and their mothers in summer: a justification for vitamin D supplementation of breast-feeding infants. J Pediatr 2003; 142(2): 169-73.
Hickey L, Gordon CM. Vitamin D deficiency: new perspectiveson and old disease. Curr Opin Endocrinol Diab 2004; 11(1): 18-25.
Nesby-O'Dell S, Scanlon KS, Cogswell ME, Gillespie C, Hollis BW, Looker AC, et al. Hypovitaminosis D prevalence and determinants among African American and white women of reproductive age: third National Health and Nutrition Examination Survey, 1988-1994. Am J Clin Nutr 2002; 76(1): 187-92.
Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF.Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr 2000; 72(3): 690-3.
Arunabh S, Pollack S, Yeh J, Aloia JF. Body fat content and 25-hydroxyvitamin D levels in healthy women. J Clin Endocrinol Metab 2003; 88(1): 157-61.
Holick MF. Environmental factors that influence the cutaneous production of vitamin D. Am J Clin Nutr 1995; 61(3Suppl): 638S-645S.
Heaney RP. Long-latency deficiency disease: insights from calcium and vitamin D. Am J Clin Nutr 2003; 78(5):912-9.
Zittermann A. Vitamin D in preventive medicine: are we ignoring the evidence? Br J Nutr 2003; 89(5): 552-72.
Holick MF. High prevalence of vitamin D inadequacy and implications for health. Mayo Clin Proc 2006; 81(3): 353-73.
Gordon CL, Halton JM, Atkinson SA, Webber CE. The contributions of growth and puberty to peak bone mass. Growth Dev Aging 1991; 55(4): 257-62.
Matkovic V, Jelic T, Wardlaw GM, Ilich JZ, Goel PK, Wright JK, et al. Timing of peak bone mass in Caucasian females and its implication for the prevention of osteoporosis. Inference from a cross-sectional model. J Clin Invest 1994; 93(2): 799-808.
Maghbooli Z, Hossein-Nezhad A, Shafaei AR, Karimi F, Madani FS, Larijani B. Vitamin D status in mothers and their newborns in Iran.BMC Pregnancy Childbirth 2007;7:1.
Ainy E, Ghazi AA, Azizi F. Changes in calcium, 25(OH) vitamin D3 and other biochemical factors during pregnancy. J Endocrinol Invest 2006; 29(4): 303-7.
Theintz G, Buchs B, Rizzoli R, Slosman D, Clavien H, Sizonenko PC, et al. Longitudinal monitoring of bone mass accumulation in healthy adolescents: evidence for a marked reduction after 16 years of age at the levels of lumbar spine and femoral neck in female subjects. J Clin Endocrinol Metab 1992; 75(4): 1060-5.
Alagöl F, Shihadeh Y, Boztepe H, Tanakol R, Yarman S, Azizlerli H, et al. Sunlight exposure and vitamin D deficiency in Turkish women. J Endocrinol Invest 2000; 23(3): 173-7.
Marwaha RK, Tandon N, Reddy DR, Aggarwal R, Singh R, Sawhney RC,et al. Vitamin D and bone mineral density status of healthy schoolchildren in northern India. Am J Clin Nutr 2005; 82(2): 477-82.
Jones G, Dwyer T. Bone mass in prepubertal children: gender differences and the role of physical activity and sunlight exposure. J Clin Endocrinol Metab 1998; 83(12): 4274-9.
Moussavi M, Heidarpour R, Aminorroaya A, Pournaghshband Z, Amini M. Prevalence of vitamin D deficiencyin Isfahani high school students in 2004. Horm Res 2005; 64(3): 144-8.
Hashemipour S, Larijani B, Adibi H, Javadi E, Sedaghat M, Pajouhi M, et al. Vitamin D deficiency and causative factors in the population of Tehran. BMC Public Health 2004; 4: 38.
Larijani B, Soltani A, Pajouhi M, Hashemipoor S, Khalilifard AR, Hamidi Z, et al. Evaluation of vitamin D deficiency and other bone biochemical factors in urban population of Tehran, winter 2001 [Online]. British Endocrine Societies Joint Meeting, 2002 April 8. Available from: URL:http://www.endocrine-abstracts.org/ea/0003/ea0003P6.htm
Du X, Greenfield H, Fraser DR, Ge K, Trube A, Wang Y.Vitamin D deficiency and associated factors in adolescentgirls in Beijing. Am J Clin Nutr 2001; 74(4): 494-500.
Mirsaeid Ghazi AA, Rais Zadeh F, Pezeshk P, Azizi F. Seasonal variation of serum 25 hydroxy D3 in residents of Tehran. J Endocrinol Invest 2004; 27(7): 676-9.
Olmez D, Bober E, Buyukgebiz A, Cimrin D. The frequency of vitamin D insufficiency in healthy female adolescents. Acta Paediatr 2006; 95(10): 1266-9.
Hatun S, Islam O, Cizmecioglu F, Kara B, Babaoglu K, Berk F, et al. Subclinical vitamin D deficiency is increased in adolescent girls who wear concealing clothing. J Nutr 2005; 135(2): 218-22.
Dahifar H, Faraji A, Ghorbani A, Yassobi S. Impact of dietary and lifestyle on vitamin D in healthy student girls aged 11-15 years. J Med Invest 2006; 53(3-4): 204-8.
Guillemant J, Allemandou A, Cabrol S, Pérès G, Guillemant S. Vitamin D status in the adolescent: seasonal variations and effects of winter supplementation with vitamin D3. Arch Pediatr 1998; 5(11): 1211-5.
Green TJ, Skeaff CM, Rockell JE, Taylor JR, Whiting SJ. Serum 25-hydroxyvitamin D status New Zealand children. Asia Pac J Clin Nutr 2004; 13(Suppl): S46.
Rahimi A, Zarghami N, Sadigh A. Relation between vitamin D and nutritional status in healthy reproductive age women. Int J Endocrinal Metab 2006; 4: 1-7.
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| Issue | Vol 47, No 3 (2009) | |
| Section | Original Article(s) | |
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| Vitamin D deficiency sunlight exposure | ||
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