Urine β2 Microglobulin and other Biochemical Indices in β Thalassemia Major
,
Abstract
To find if some indices have predictive value for renal complications. We conducted a cross sectional and included 80 patients with the age ranged 5-17 years, all with the proven diagnosis of β-thalassemia major. A urine and 5 ml of blood sample were obtained from all of the cases. Biochemical indices such as serum levels of creatinine, Na, Mg, Hb, and ferritin and also urine levels of Na, Mg, creatinine and β2 microglobulin was measured. All data analysis was performed using SPSS 14.0. P-Spearman test was applied to assess correlation between urine beta-2-microglobulin and other variables. Patients GFR was in normal range. Abnormal level of urine β2 microglobulin was reported in 44 patients (55%). P Spearman test proved correlation only between urine β2 microglobulin and FE-Mg. We concluded that renal proximal tubular dysfunction may oocur in children with β thalassemia major without clinical manifestations of renal dysfunction or decrease in GFR. We warn not to rely only on GFR as a early indicator for renal complications among children with β thalassemia major.
Cooley TB and Lee P. A series of cases of splenomegaly and peculiar bone changes. Trials Am Pediatr Soc 1925; 37: 29-90.
Stuart HO. The Thalassemia. In: Natan and Oskis,editors. Hematology of childhood. Williams & Wilkins 2003;P.842-919.
Elliott P. Vichinsky, Eric A. MacKlin, John S. Waye, Fred Lorey, and Nancy F. Olivieri. Changes in the Epidemiology of Thalassemia in North America: A new Minority Disease. Pediatrics 2005; 116: 818 - 825.
Koliakos G, Popachristous F, Koussi A, Perifanis V, Tsatra I, Athanasio M. Urine biochemical markers of early renal dysfunction are associated with iron overload in beta thalassemia. Clin Lab Haematol 2003; 25 (2): 105-9.
Aldudak B, Karaday Bayazit A, 5oyan A, Ozel A, Anarat A, Sasmaz I. Renal function in pediatric with beta thalassemia major. Pediatr Nephrol 2000; 15 (1-2): 109-12.
Cianciulli P. Early detection of nephrotoxic effect in thalassemia patients receiving deferoxamine. Kidney Int 1994; 46: 467-70.
Tabatabaei SMT and Tabatabaei SM. GFR in patients with thalassemia major. ZUMS 2000; 1-2: 1-6. [Persian]
Keith Quirolo , Elliott Vichinsky . Hemoglobin Disorders.In: Behrman RE, Killegman RM, Jenson HB. Nelson Textbook of pediatrics 17 th ed. Philadelphia, WB Saunders Co, 2007; 2033-2037.
Theodoridis C, Ladis V, Papatheodorou A. Growth and management of short stature in thalassemia major. Pediatr Endocrinol Metab 1998; 11: 835-44.
Butthep P, Nuchprayoon I, Futrakul N. Endothelial injury and altered hemodynamics in thalassemia. Clin Hemirheol Microcir 2004; 31 (4): 287-93.
Kalman S, Atay AA, Sakallioglu O, Ozgurtas T, Gok F, Kurt I. Renal tubular function in children with beta thalassemia minor. Nephrology 2005; 10(5): 427-9.
Mohkam M, 5ariman Sh, Shamsian Sh. Urine NAG and associated factors in patients with thalassemia major. Pazhoohandeh 2005; 10 (45): 177-181. [Persian]
Koren G, Bentur Y, Strong D. Acute changes in renalfunction associated with deferoxamine therapy. Am J DisChild 1989; 144: 1069-1070.
| Files | ||
| Issue | Vol 47, No 6 (2009) | |
| Section | Original Article(s) | |
| Keywords | ||
| β thalassemia β2 microglobulin FE-Mg proximal tubular | ||
| Rights and permissions | |
|
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
