Clinical Feature of Extranodal Presentation of Non Hodgkin Lymphoma in Head and Neck
Abstract
Non Hodgkin lymphoma (NHL) constitutes 5% of all head & neck cancer. The incidence of it has been increased over the last four decades. One of main characteristic of NHL is extranodal presentation that has different pattern in various part of world. A retrospective was designed in a tertiary referral center. It has been done between January 1996 and March 2006. All clinical and pathological characteristics were evaluated. 129 patients were included in this study, 89 male and 49 female. The mean age was 49 year. The most common site of involvement was Waldeyer's ring and the most common presenting symptom was cervical mass. 48% of patients had lymphadenopathy and 12% had B symptom. The most common histologic type was diffuse large cell lymphoma. In our series male to female ratio was 2.2 that are more than other studies .it seems that extranodal presentation is more common in Iranian patients than other population.
Freeman C, Berg JW, Cutler SJ. Occurrence and prognosis of extranodal lymphomas. Cancer 1972;29(1):252-60.
Salem P, Anaissie E, Allam C, Geha S, Hashimi L, Ibrahim N, et al. Non-Hodgkin's lymphomas in the Middle East. A study of 417 patients with emphasis on special features. Cancer 1986;58(5):1162-6.
Reddy S, Pellettiere E, Saxena V, Hendrickson FR. Extranodal non-Hodgkin's lymphoma. Cancer 1980;46(9):1925-31.
Ree HJ, Rege VB, Knisley RE, Thayer WR, D'Amico RP, Song JY, et al. Malignant lymphoma of Waldeyer's ring following gastrointestinal lymphoma. Cancer1980;46(7):1528-35.
Duncan PR, Checa F, Gowing NF, McElwain TJ, PeckhamMJ. Extranodal non-Hodgkin's lymphoma presenting in thetesticle: a clinical and pathologic study of 24 cases. Cancer1980;45(7):1578-84.
Shima N, Kobashi Y, Tsutsui K, Ogawa K, Maetani S, NakashimaY, et al. Extranodal non-Hodgkin's lymphoma ofthe head and neck. A clinicopathologic study in the Kyoto- Nara area of Japan. Cancer 1990;66(6):1190-7.
Tondini C, Giardini R, Bozzetti F, Valagussa P, Santoro A, Bertulli R, et al. Combined modality treatment for primarygastrointestinal non-Hodgkin's lymphoma: the Milan CancerInstitute experience. Ann Oncol 1993;4(10):831-7.
Zinzani PL, Magagnoli M, Ascani S, Ricci P, Poletti V,,Gherlinzoni F, et al. Nongastrointestinal mucosa-associated lymphoid tissue (MALT) lymphomas: clinical and therapeutic features of 24 localized patients. Ann Oncol1997;8(9):883-6.
Arican A, Dinçol D, Akbulut H, Onur H, Demirkazik A, Cay F, et al. Clinicopathologic features and prognostic factorsof primary extranodal non-Hodgkin's lymphomas in Turkey. Am J Clin Oncol 1999;22(6):587-92.
Economopoulos T, Asprou N, Stathakis N, PapageorgiouE, Dervenoulas J, Xanthaki K, et al. Primary extranodal non-Hodgkin's lymphoma in adults: clinicopathological and survival characteristics. Leuk Lymphoma 1996;21(1-2):131-6.
d'Amore F, Christensen BE, Brincker H, Pedersen NT, Thorling K, Hastrup J, et al. Clinicopathological features and prognostic factors in extranodal non-Hodgkin lymphomas. Danish LYFO Study Group. Eur J Cancer 1991;27(10):1201-8.
Zhou J, Wei L, Cao Y. Analysis on clinical and immunohistochemical characteristics of primary extranodular non-Hodgkin's lymphoma in otolaryngol head and neck. Lin Chuang Er Bi Yan Hou Ke Za Zhi 2003;17(12):724-6.
Goldwein JW, Coia LR, Hanks GE. Prognostic factors in patients with early stage non-Hodgkin's lymphomas of thehead and neck treated with definitive irradiation. Int J Radiat Oncol Biol Phys 1991;20(1):45-51.
Enrique A, Quesada JL, Lorente J, López D. Hodgkin andNon-Hodgkin lymphomas in otorhinolaryngology. Acta Otorrinolaringol Esp 2004;55(8):387-9.
DePeña CA, Van Tassel P, Lee YY. Lymphoma of the head and neck. Radiol Clin North Am 1990;28(4):723-43.
Zucca E, Roggero E, Bertoni F, Conconi A, Cavalli F. Primary extranodal non-Hodgkin's lymphomas. Part 2: Head and neck, central nervous system and other less common sites. Ann Oncol 1999;10(9):1023-33.
Yuen A, Jacobs C. Lymphomas of the head and neck. Semin Oncol 1999;26(3):338-45.
Nayak LM, Deschler DG. Lymphomas. Otolaryngol Clin North Am 2003;36(4):625-46.
Ezzat AA, Ibrahim EM, El Weshi AN, Khafaga YM, Al- Jurf M, Martin JM, et al. Localized non-Hodgkin's lymphoma of Waldeyer's ring: clinical features, management, and prognosis of 130 adult patients. Head Neck 2001;23(7):547-58.
Yuen A, Jacobs C. Lymphomas of the head and neck. Semin Oncol 1999;26(3):338-45.
Sarpel SC, Paydas S, Tuncer I, Varinli S, Koksal M, Akoglu T. Non-Hodgkin's lymphomas in Turkey. Cancer 1988;62(8):1653-7.
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Issue | Vol 47, No 6 (2009) | |
Section | Original Article(s) | |
Keywords | ||
Head & neck neoplasms lymphoma non-Hodgkin |
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