Pregnancy Outcome of Chorionic Villus Sampling on 260 Couples with Beta- Thalassemia Trait in North of Iran


Chorionic villus sampling (CVS) is a new method and its true risk of fetal loss and complications is not still clearly determined. The objective of this study was to review the clinical pregnancy outcome of transabdominal CVS (TA-CVS) performed on women with minor beta thalassemia. TA-CVS performed on 300 women with a singleton pregnancy and we could follow 213 women until delivery. Data regarding induced legal abortion, spontaneous abortion, vaginal leakage, Vaginal bleeding and deformity of extremities ( limb reduction) were obtained by questionnaire in five years. All CVS were performed by one operator. The mean gestation at time of CVS was 82.4±11.3 days. 79.2% of the procedures were made between 10-13 completed weeks and in other women (20.7%) TA-CVS was performed at 13-16 weeks. The majority (86.9%) required only one puncture. There were 47 pregnancy terminations because of fetal major beta thalassemia diagnosis (18 %). The rate of spontaneous abortion in our study was over ally (1.4%) and in two patients vaginal bleeding was noticed. We didn't find any vaginal leakage and limb reduction in our survey. TA-CVS is an accurate and safe procedure in experienced hands. It should be considered as one of the safe available procedures for women who require prenatal genetic diagnosis and wish to receive earlier diagnostic information for probable termination of pregnancy.

Najmabadi H, Teimourian SH, Khatibi T, Neishabury M, Pourfarzad F, Jalil Nejad S, et al. Amplification refractory mutation system and reverse hybrization in the detection of thalassemia in Iran. Arch of Iranian Med 2001;4(4):165-70.

Cunningham FG, Leveno KJ, Bloom SL, Hauth JC, Gilstrap LC, Wenstrom KD. Williams Obstetrics. 22nd ed. New York: McGraw-Hill; 2005. p. 328-30.

Caughey AB, Hopkins LM, Norton ME. Chorionic villus sampling compared with amniocentesis and the difference in the rate of pregnancy loss. Obstet Gynecol 2006;108(3 Pt 1):612-6.

Greenough A, Yuksel B, Naik S, Cheeseman P, Nicolaides KH. First trimester invasive procedures: effects on symptom status and lung volume in very young children. Pediatr Pulmonol 1997;24(6):415-22.

Randomised trial to assess safety and fetal outcome of early and midtrimester amniocentesis. The Canadian Early and Mid-trimester Amniocentesis Trial (CEMAT) Group. Lancet 1998;351(9098):242-7.

Philip J, Silver RK, Wilson RD, Thom EA, Zachary JM, Mohide P, et al. Late first-trimester invasive prenatal diagnosis: results of an international randomized trial. Obstet Gynecol 2004;103(6):1164-73.

Papp C, Beke A, Mezei G, Tóth-Pál E, Papp Z. Chorionic villus sampling: a 15-year experience. Fetal Diagn Ther 2002;17(4):218-27.

Evans MI, Wapner RJ. Invasive prenatal diagnostic procedures 2005. Semin Perinatol 2005;29(4):215-8.

Kucerová I, Krofta L, Benegová O. Complications of the invasive prenatal diagnostic methods. Ceska Gynekol 2004;69 Suppl 1:28-32.

Caughey AB, Hopkins LM, Norton ME. Chorionic villus sampling compared with amniocentesis and the difference in the rate of pregnancy loss. Obstet Gynecol 2006;108(3 Pt 1):612-6.

Brambati B, Tylui L. Choorionic villus sampling and amniocentesis. Curr Opin Obstet Gynecol 2005;17(2):197-201.

Brambati B, Tului L, Camurri L, Guercilena S. Early second trimester (13 to 20 weeks) transabdominal chorionic villus sampling (TA-CVS): a safe and alternative method for both high and low risk populations. Prenat Diagn2002;22(10):907-13.

Scott F, Peters H, Boogert T, Robertson R, Anderson J, McLennan A, et al. The loss rates for invasive prenatal testing in a specialised obstetric ultrasound practice. Aust N Z J Obstet Gynaecol 2002;42(1):55-8.

Mujezinovic F, Alfirevic Z. Procedure-related complications of amniocentesis and chorionic villous sampling: a systematic review. Obstet Gynecol 2007;110(3):687-94.

Golden CM, Ryan LM, Holmes LB. Chorionic villus sampling: a distinctive teratogenic effect on fingers? Birth Defects Res A Clin Mol Teratol 2003;67(8):557-62.

Vandenbossche F, Horovitz J, Guyon F, Verret C, Saura R. Pain experience during chorionic villus sampling and amniocentesis: a preliminary study. Eur J Obstet Gynecol Reprod Biol 2008;136(2):189-93.

Cavallotti D, Casilla G, Piantelli G, Verrotti C, Fieni S, Gramellini D. Early complications of prenatal invasive diagnostics: perspective analysis. Acta Biomed 2004;75 Suppl 1:23-6.

Jauniaux E, Pahal GS, Rodeck CH. What invasive procedure to use in early pregnancy? Baillieres Best Pract Res Clin Obstet Gynaecol 2000;14(4):651-62.

Cederholm M, Haglund B, Axelsson O. Infant morbidity following amniocentesis and chorionic villus sampling for prenatal karyotyping. BJOG 2005;112(4):394-402.

Lau KT, Leung YT, Fung YT, Chan LW, Sahota DS, Leung NT. Outcome of 1,355 consecutive transabdominal chorionic villus samplings in 1,351 patients. Chin Med J (Engl) 2005;118(20):1675-81.

Tabor A, Philip J, Madsen M, Bang J, Obel EB, Nørgaard- Pedersen B. Randomised controlled trial of geneticamniocentesis in 4606 low-risk women. Lancet 1986;1(8493):1287-93.

Schaap AH, van der Pol HG, Boer K, Leschot NJ, Wolf H. Long-term follow-up of infants after transcervical chorionic villus sampling and after amniocentesis to compare congenital abnormalities and health status. Prenat Diagn 2002;22(7):598-604.

IssueVol 48, No 3 (2010) QRcode
Chorionic villi sampling beta- thalassemia pregnancy outcome

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
Asnafi N, Akhavan Niaki H. Pregnancy Outcome of Chorionic Villus Sampling on 260 Couples with Beta- Thalassemia Trait in North of Iran. Acta Med Iran. 48(3):168-171.