Relation between Preoperative Mild Increased in Serum Creatinine Level and Early Outcomes after Coronary Artery Bypass Grafting

  • Hassan Radmehr Cardiovascular Surgery Department, Imam Khomeini Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
  • Seyed Khalil Forouzannia Cardiovascular Research Center, Afshar Hospital, Shahid Sadooghi University of Medical Sciences, Yazd, Iran.
  • Ali Reza Bakhshandeh Cardiovascular Surgery Department, Imam Khomeini Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
  • Mehdi Sanatkar Mail Cardiovascular Surgery Department, Imam Khomeini Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
Serum creatinine, Coronary artery bypass graft surgery, Early mortality


This study evaluates the effect of preoperative increased level of serum creatinine (Cr) on early outcomes after coronary artery bypass graft surgery (CABG). 1140 patients who underwent CABG in our center were studied. Patients with Cr >2.25 mg/dl or preoperative dialysis and who had off-pump operations were excluded. Group 1 consisted of 892 patients with normal Cr (0.5-1.2 mg/dl) and group 2 consisted of 248 (21.8%) patients with mild increased level of serum Cr (1.3-2.2 mg/dl). Patients in group 1 were younger than group 2. There were more patients with hypertension in group 2, but there were not statistically significant difference between two groups in terms of the frequency of diabetes, smoking, cerebrovascular disease and New York Heart Association (NYHA) class. Left ventricular ejection fraction (LVEF) was lower in group 2. Cardiopulmonary bypass time (CPB) was longer in group 2. Early mortality was 3.2% in group 1 and 8.4% in group 2 (P<0.001). Prolonged ICU stay, low cardiac output, prolonged mechanical ventilation, postoperative atrial fibrillation, postoperative re-exploration and sepsis were more frequent in group 2. Mild increase in serum Cr level preoperatively is a marker of increased early mortality and outcome after CABG.


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How to Cite
Radmehr H, Forouzannia SK, Bakhshandeh AR, Sanatkar M. Relation between Preoperative Mild Increased in Serum Creatinine Level and Early Outcomes after Coronary Artery Bypass Grafting. Acta Med Iran. 49(2):89-92.