Metastatic Brain Tumors: A Retrospective Review in East Azarbyjan (Tabriz)
A set of one hundred and twenty nine patients with known primary malignancy and suspected brain metastasis was reviewed in present study. The patients were selected among patients presented to the MRI section of Imam Khomeini Hospital or a private MRI center in Tabriz (Iran). Primary tumor site, clinical manifestations, number and site of lesions were identified in this patient population. The primary tumor site was breast in 55 patients (42.6%), followed by lung (40.3%), kidney (7.7%), colorectal (4.6%), lymphoma (3.1%) and melanoma (1.5%). Most patients were presented with features of increased intracranial pressure (headaches and vomiting), seizures and focal neurologic signs. Single brain metastasis occurred in 16.3% of patients, while multiple lesions accounted for 83.7% of patients. Ninety seven patients had supratentorial metastases (75.2%). Twenty cases (15.5%) had metastases in both compartments. Infratentorial lesions were observed only in twelve patients (9.3%).
Wen PY, Loeffler JS. Management of brain metastases. Oncology (Williston Park) 1999;13(7):941-54, 957-61; discussion 961-2, 9.
Johnson JD, Young B. Demographics of brain metastasis. Neurosurg Clin N Am 1996;7(3):337-44.
Davey P. Brain metastases: treatment options to improve outcomes. CNS Drugs 2002;16(5):325-38.
Eichler AF, Loeffler JS. Multidisciplinary management of brain metastases. Oncologist 2007;12(7):884-98.
Sze G, Milano E, Johnson C, Heier L. Detection of brain metastases: comparison of contrast-enhanced MR with unenhanced MR and enhanced CT. AJNR Am J Neuroradiol 1990;11(4):785-91.
Soffietti R, Rudā R, Mutani R. Management of brain metastases. J Neurol 2002;249(10):1357-69.
Delattre JY, Krol G, Thaler HT, Posner JB. Distribution of brain metastases. Arch Neurol 1988;45(7):741-4.
Suzuki K, Yamamoto M, Hasegawa Y, Ando M, Shima K, Sako C, Ito G, Shimokata K. Magnetic resonance imaging and computed tomography in the diagnoses of brain metastases of lung cancer. Lung Cancer 2004;46(3):357-60.
Schellinger PD, Meinck HM, Thron A. Diagnostic= accuracy of MRI compared to CCT in patients with brain metastases. J Neurooncol 1999;44(3):275-81.
Hochstenbag MM, Twijnstra A, Wilmink JT, Wouters EF, ten Velde GP. Asymptomatic brain metastases (BM) in small cell lung cancer (SCLC): MR-imaging is useful at initial diagnosis. J Neurooncol 2000;48(3):243-8.
Leoffler JS, Patchell RA, Sawaya R. Metastatic brain cancer. In: DeVita VT Jr, Hellman S, Rosenberg SA, editors. Cancer: Principles and Practice of Oncology. 5th ed. Philadelphia: Lippincott-Raven; 1997. p. 2523-6.
Posner JB. Management of brain metastases. Rev Neurol (Paris) 1992;148(6-7):477-87.
Sundermeyer ML, Meropol NJ, Rogatko A, Wang H, Cohen SJ. Changing patterns of bone and brain metastases in patients with colorectal cancer. Clin Colorectal Cancer 2005;5(2):108-13.
Bouffet E, Doumi N, Thiesse P, Mottolese C, Jouvet A, Lacroze M, Carrie C, Frappaz D, Brunat-Mentigny M. Brain metastases in children with solid tumors. Cancer 1997;79(2):403-10.
Lassman AB, DeAngelis LM. Brain metastases. Neurol Clin 2003;21(1):1-23, vii.
Barnholtz-Sloan JS, Sloan AE, Davis FG, Vigneau FD, Lai P, Sawaya RE. Incidence proportions of brain metastases in patients diagnosed (1973 to 2001) in the Metropolitan Detroit Cancer Surveillance System. J Clin Oncol 2004;22(14):2865-72.
Subramanian A, Harris A, Piggott K, Shieff C, Bradford R. Metastasis to and from the central nervous system: the 'relatively protected site'. Lancet Oncol 2002;3(8):498-507.
Wen PY, Black PM, Loeffler JS. Treatment of metastatic cancer. In: DeVita VT Jr, Hellman S, Rosenberg SA, editors. Cancer: Principles and Practice of Oncology. 6th ed. Philadelphia, Pa: Lippincott Williams and Wilkins; 2001. p. 2655-70.
Biswas G, Bhagwat R, Khurana R, Menon H, Prasad N, Parikh PM. Brain metastasis: evidence based management. J Cancer Res Ther 2006;2(1):5-13.
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