Antimicrobial Resistant Pattern of Escherichia coli Strains Isolated from Pediatric Patients in Jordan
Abstract
The present study was conducted to investigate antimicrobial resistant pattern of Escherichia coli (E. coli) strains isolated from clinical specimens of Jordanian pediatric patients during the period from January to December 2008. A total of 444 E. coli strains were isolated from clinical specimens and tested for their susceptibility to different antimicrobial drugs. Overall, high resistance rate was observed for ampicillin (84%), followed by amoxicillin-clavulanic acid (74.3%), cotrimoxazole (71%), nalidixic acid (47.3%), cephalothin (41%). Lower resistance rates were observed for amikacin (0%) followed by Cefotaxime (11%), Ceftriaxone (11.7%), ciprofloxacin (14.5%), Norfloxacin (16.5%), gentamicin (17.3%) cephalexin (20.9%), Ceftazidime (22.5%), cefixime (29.6%), and cefaclor (32.8%). Ampicillin, amoxicillin-clavulanic acid and cotrimoxazole were found to be ineffective at in vitro inhibition of the E. coli of pediatric origin. Amikacin was highly effective for E. coli with susceptibility rate of 100%. The majority of E. coli strains were susceptible to third generation cephalosporins and fluoroquinolones.
Helms M, Vastrup P, Gerner-Smidt P, Mølbak K. Excess mortality associated with antimicrobial drug-resistant Salmonella typhimurium. Emerg Infect Dis 2002;8(5):490-5.
Travers K, Barza M. Morbidity of infections caused by antimicrobial-resistant bacteria. Clin Infect Dis 2002;34 Suppl 3:S131-4.
Byarugaba DK. A view on antimicrobial resistance indeveloping countries and responsible risk factors. Int J Antimicrob Agents 2004;24(2):105-10.
Okeke IN, Lamikanra A, Edelman R. Socioeconomic and behavioral factors leading to acquired bacterial resistance to antibiotics in developing countries. Emerg Infect Dis 1999;5(1):18-27.
Tobih JE, Taiwo SS, Olowe OA, Olaosun OA, Adejumao SD. Clinical and microbiological profiles of ear infections in Osogbo, Nigeria. Trop Doct 2006;36(3):165-6.
Bartoloni A, Bartalesi F, Mantella A, Dell'Amico E, Roselli M, Strohmeyer M, Barahona HG, Barrón VP, Paradisi F, Rossolini GM. High prevalence of acquired antimicrobial resistance unrelated to heavy antimicrobial consumption. J Infect Dis 2004;189(7):1291-4
McDermott PF, Walker RD, White DG. Antimicrobials: modes of action and mechanisms of resistance. Int J Toxicol 2003;22(2):135-43.
Mølbak K, Baggesen DL, Aarestrup FM, Ebbesen JM, Engberg J, Frydendahl K, Gerner-Smidt P, Petersen AM, Wegener HC. An outbreak of multidrug-resistant, quinolone-resistant Salmonella enterica serotype typhimurium DT104. N Engl J Med 1999;341(19):1420-5.
Burwen DR, Banerjee SN, Gaynes RP. Ceftazidime resistance among selected nosocomial gram-negative bacilli in the United States. National Nosocomial Infections Surveillance System. J Infect Dis 1994;170(6):1622-5.
Bauer AW, Kirby WM, Sherris JC, Turck M. Antibiotic susceptibility testing by a standardized single disk method. Am J Clin Pathol 1966;45(4):493-6.
Rushton HG. Urinary tract infections in children.Epidemiology, evaluation, and management. Pediatr ClinNorth Am 1997;44(5):1133-69.
Karlowsky JA, Jones ME, Draghi DC, Thornsberry C, Sahm DF, Volturo GA. Prevalence and antimicrobial= susceptibilities of bacteria isolated from blood cultures of hospitalized patients in the United States in 2002. Ann Clin Microbiol Antimicrob 2004;3:7.
Younis N, Quol K, Al-Momani T, Al-Awaisheh F, Al- Kayed D. Antibiotic resistance in children with recurrent or complicated urinary tract infection. JNMA J Nepal Med Assoc 2009;48(173):14-9.
Haghi-Ashteiani M, Sadeghifard N, Abedini M, Soroush S, Taheri-Kalani M. Etiology and antibacterial resistance of bacterial urinary tract infections in Children’s Medical Center, Tehran, Iran. Acta Med Iran 2007;45(2):153-7.
Aibinu I, Adenipekun E, Odugbemi T. Emergence of Quinolone Resistance amongst Escherichia coli strains isolated from clinical infections in some Lagos State Hospitals in Nigeria. Nigerian J Health and Biomed Sci2004;3(2):73-8.
Hasan MN, Mahal J, Mou SM, Shamim Kabir AHM, slam MJ. Susceptibility of Escherichia Coli isolated from blood stream. J Innov Dev Strategy 2008;2(2):34-7.
Abdul-Sahib KY. Study of Ciprofloxacin Resistant Escherichia coli (CREC) in Type 2 Diabetic Patients with Symptomatic Urinary Tract Infections. Iraqi J Comm Med 2008;21:58-63.
Ranjbar R , Haghi-Ashtiani MT, Jonaidi Jafari N, Abedini M. The prevalence and antimicrobial susceptibility of bacterial uropathogens isolated from pediatric patients. Iranian J Publ Health 2009;38(2):134-8.
El Astal Z. Increasing ciprofloxacin resistance among prevalent urinary tract bacterial isolates in Gaza Strip, Palestine. J Biomed Biotechnol 2005;2005(3):238-41.
Dimitrov TS, Udo EE, Emara M, Awni F, Passadilla R. Etiology and antibiotic susceptibility patterns of community-acquired urinary tract infections in a Kuwait hospital. Med Princ Pract 2004;13(6):334-9.
| Files | ||
| Issue | Vol 49, No 5 (2011) | |
| Section | Original Article(s) | |
| Keywords | ||
| Antimicrobial resistant Escherichia coli Pediatric patients | ||
| Rights and permissions | |
|
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
